Novel Application of Photo-Crosslinked Urocanic-Acid-Modified Chitosan in Corneal Wounds
Lee AL, Hsieh HY, Chen YY, Tsai LH, Wey SL, Chen D, Chen YJ, Young TH (2022)
Publication Type: Journal article
Publication year: 2022
Journal
DOI: 10.1021/acsbiomaterials.2c00050
Abstract
In the last few years, the use of tissue adhesives in corneal perforation has gained immense popularity in clinical practices. The present study aimed to devise a new application of urocanic-acid-modified chitosan (CS) with methylene blue (MB) as a photosensitizer for the development of a photo-crosslinked tissue adhesive. In particular, the curing time was controlled with the aid of a 650 nm red diode. Under the same irradiation condition, the mechanical properties were tuned using the photosensitizer at different concentrations. In vitro tests revealed that the gel was ductile and biocompatible. The application of the gel to a perforated cornea model stopped the leakage of aqueous humor, immediately after the gel was photo-crosslinked. The blue appearance of the gel provided high precision when applied to corneal wounds. Importantly, the crosslinked gel became transparent within 24 h, owing to the dissipation of MB from tears, and the gel spontaneously sloughed off without artificial removal. Altogether, the study reported the development of a novel photo-crosslinkable urocanic-acid-modified CS gel that exhibited significant potential to be utilized in the healing of corneal perforation.
Authors with CRIS profile
Involved external institutions
National Taiwan University (NTU)
Taiwan (TW)
Mackay Memorial Hospital / 馬偕紀念醫院
Taiwan (TW)
National Taiwan University Hospital (NTUH) / 國立台灣大學醫學院附設醫院
Taiwan (TW)
Taiwan (TW)
Mackay Memorial Hospital / 馬偕紀念醫院
Taiwan (TW)
National Taiwan University Hospital (NTUH) / 國立台灣大學醫學院附設醫院
Taiwan (TW)
How to cite
APA:
Lee, A.L., Hsieh, H.Y., Chen, Y.Y., Tsai, L.H., Wey, S.L., Chen, D.,... Young, T.H. (2022). Novel Application of Photo-Crosslinked Urocanic-Acid-Modified Chitosan in Corneal Wounds. ACS Biomaterials Science and Engineering. https://dx.doi.org/10.1021/acsbiomaterials.2c00050
MLA:
Lee, An Li, et al. "Novel Application of Photo-Crosslinked Urocanic-Acid-Modified Chitosan in Corneal Wounds." ACS Biomaterials Science and Engineering (2022).
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