Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors

Zhou J, Zaiss M, Knutsson L, Sun PZ, Ahn SS, Aime S, Bachert P, Blakeley JO, Cai K, Chappell MA, Chen M, Gochberg DF, Goerke S, Heo HY, Jiang S, Jin T, Kim SG, Laterra J, Paech D, Pagel MD, Park JE, Reddy R, Sakata A, Sartoretti-Schefer S, Sherry AD, Smith SA, Stanisz GJ, Sundgren PC, Togao O, Vandsburger M, Wen Z, Wu Y, Zhang Y, Zhu W, Zu Z, Van Zijl PCM (2022)

Publication Type: Journal article, Review article

Publication year: 2022

Journal

DOI: 10.1002/mrm.29241

Abstract

Amide proton transfer-weighted (APTw) MR imaging shows promise as a biomarker of brain tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially among different institutes, and there are no agreed-on standards in the imaging community. Therefore, the results acquired from different research centers are difficult to compare, which hampers uniform clinical application and interpretation. This paper reviews current clinical APTw imaging approaches and provides a rationale for optimized APTw brain tumor imaging at 3 T, including specific recommendations for pulse sequences, acquisition protocols, and data processing methods. We expect that these consensus recommendations will become the first broadly accepted guidelines for APTw imaging of brain tumors on 3 T MRI systems from different vendors. This will allow more medical centers to use the same or comparable APTw MRI techniques for the detection, characterization, and monitoring of brain tumors, enabling multi-center trials in larger patient cohorts and, ultimately, routine clinical use.

Authors with CRIS profile

Involved external institutions

Vanderbilt University Medical Center United States (USA) (US) Deutsches Krebsforschungszentrum (DKFZ) Germany (DE) Johns Hopkins University (JHU) United States (USA) (US) University of Pittsburgh United States (USA) (US) Sungkyunkwan University (SKKU) Korea, Republic of (KR) University of Texas MD Anderson Cancer Center United States (USA) (US) University of Ulsan / 울산대학교 Korea, Republic of (KR) University of Pennsylvania United States (USA) (US) Kyoto University / 京都大学 Kyōto daigaku Japan (JP) Kantonsspital Winterthur (KSW) Switzerland (CH) University of Texas Southwestern Medical Center (UT Southwestern) United States (USA) (US) Lund University / Lunds universitet Sweden (SE) Max-Planck-Institut für biologische Kybernetik / Max Planck Institute for Biological Cybernetics Germany (DE) Emory University United States (USA) (US) Yonsei University Korea, Republic of (KR) University of Turin / Università degli Studi di Torino (UNITO) Italy (IT) University of Illinois at Urbana-Champaign United States (USA) (US) University of Nottingham United Kingdom (GB) University of Toronto Canada (CA) Kyushu University / 九州大学 Japan (JP) University of California, Berkeley United States (USA) (US) Southern Medical University / 南方医科大学 China (CN) Chinese Academy of Sciences (CAS) / 中国科学院 China (CN) Zhejiang University China (CN) Huazhong University of Science & Technology China (CN)

How to cite

APA:

Zhou, J., Zaiss, M., Knutsson, L., Sun, P.Z., Ahn, S.S., Aime, S.,... Van Zijl, P.C.M. (2022). Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors. Magnetic Resonance in Medicine. https://dx.doi.org/10.1002/mrm.29241

MLA:

Zhou, Jinyuan, et al. "Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors." Magnetic Resonance in Medicine (2022).

BibTeX: Download