Autologous regulatory T-cell transfer in refractory ulcerative colitis with concomitant primary sclerosing cholangitis

Voskens C, Stoica D, Rosenberg M, Vitali F, Zundler S, Ganslmayer M, Knott H, Wiesinger M, Wunder J, Kummer M, Siegmund B, Schnoy E, Rath T, Hartmann A, Hackstein H, Schuler-Thurner B, Berking C, Schuler G, Atreya R, Neurath M (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Gut BMJ Publishing Group

DOI: 10.1136/gutjnl-2022-327075

Abstract

Objective Ulcerative colitis (UC) is a chronic, debilitating immune-mediated disease driven by disturbed mucosal homeostasis, with an excess of intestinal effector T cells and an insufficient expansion of mucosal regulatory T cells (Tregs). We here report on the successful adoptive transfer of autologous, ex vivo expanded Tregs in a patient with refractory UC and associated primary sclerosing cholangitis (PSC), for which effective therapy is currently not available.

Authors with CRIS profile

Caroline Bosch-Voskens Department of Dermatology Francesco Vitali Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Sebastian Zundler Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Marion Ganslmayer Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Heike Knott Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Timo Rath Juniorprofessur für Molekulare Endoskopie Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Holger Hackstein Professur für Transfusionsmedizin und Cell-Engineering Beatrice Schuler-Thurner Medizinische Fakultät Carola Berking Lehrstuhl für Haut- und Geschlechtskrankheiten Gerold Schuler Lehrstuhl für Haut- und Geschlechtskrankheiten Raja Atreya Professur für Translationale Immunforschung bei chronisch entzündlichen Darmerkrankungen (Heisenberg-Professur) Markus Neurath Lehrstuhl für Innere Medizin I

Additional Organisation(s)

Professur für Translationale Immundermatologie

Involved external institutions

Charité - Universitätsmedizin Berlin DE Germany (DE) Universitätsklinikum Augsburg DE Germany (DE)

How to cite

APA:

Voskens, C., Stoica, D., Rosenberg, M., Vitali, F., Zundler, S., Ganslmayer, M.,... Neurath, M. (2022). Autologous regulatory T-cell transfer in refractory ulcerative colitis with concomitant primary sclerosing cholangitis. Gut. https://doi.org/10.1136/gutjnl-2022-327075

MLA:

Voskens, Caroline, et al. "Autologous regulatory T-cell transfer in refractory ulcerative colitis with concomitant primary sclerosing cholangitis." Gut (2022).

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