Feedback-Induced and Oscillating pH Regulation of a Binary Enzyme-Polymersomes System

Wang X, Moreno S, Boye S, Wen P, Zhang K, Formanek P, Lederer A, Voit B, Appelhans D (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Chemistry of Materials American Chemical Society

Book Volume: 33

Pages Range: 6692-6700

Journal Issue: 17

DOI: 10.1021/acs.chemmater.1c00897

Abstract

The stimuli-triggered regulating ability is a basic characteristic of biological systems, and it is always cyclic in nature. To mimic this stimuli-triggered regulation process for the construction of artificial cellular structures and functions is a challenge. Here, we present the development of artificial organelles system (AOS) with stimuli-trigged regulation ability consisting of the coexisting glucose oxidase-(GOx)-loaded pH-responsive polymersomes A (GOx-Psomes A) and urease-loaded pH-responsive polymersomes B (Urease-Psomes B) with orthogonal-responsive membranes. The addition of chemical fuels triggers the out-of-equilibrium state of AOS at which the pH decreases (glucose as fuel) or increases (urea as fuel). The pH change results in the catalytic "on"or "off"switch of GOx-Psomes A and Urease-Psomes B at different states due to their different pH responsiveness. Thus, this AOS with feedback-induced and oscillating pH-regulating ability paves the way for the construction of artificial eukaryotic cell biomimetics with controlled communications and metabolism mimicking.

Involved external institutions

Leibniz-Institut für Polymerforschung Dresden e. V. DE Germany (DE) Harbin Institute of Technology (HIT) / 哈工大 CN China (CN)

How to cite

APA:

Wang, X., Moreno, S., Boye, S., Wen, P., Zhang, K., Formanek, P.,... Appelhans, D. (2021). Feedback-Induced and Oscillating pH Regulation of a Binary Enzyme-Polymersomes System. Chemistry of Materials, 33(17), 6692-6700. https://doi.org/10.1021/acs.chemmater.1c00897

MLA:

Wang, Xueyi, et al. "Feedback-Induced and Oscillating pH Regulation of a Binary Enzyme-Polymersomes System." Chemistry of Materials 33.17 (2021): 6692-6700.

BibTeX: Download