Dynamic Docking and Undocking Processes Addressing Selectively the Outside and Inside of Polymersomes

Iyisan B, Siedel AC, Gumz H, Yassin M, Kluge J, Gaitzsch J, Formanek P, Moreno S, Voit B, Appelhans D (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Macromolecular Rapid Communications Wiley-VCH Verlag

Book Volume: 38

Article Number: 1700486

Journal Issue: 21

DOI: 10.1002/marc.201700486

Abstract

Increasing complexity and diversity of polymersomes and their compartments is a key issue for mimicking cellular functions and protocells. Thus, new challenges arise in terms of achieving tunable membrane permeability and combining it with control over the membrane diffusion process, and thus enabling a localized and dynamic control of functionality and docking possibilities within or on the surface of polymeric compartments. This study reports the concept of polymersomes with pH-tunable membrane permeability for controlling sequential docking and undocking processes of small molecules and nanometer-sized protein mimics selectively on the inside and outside of the polymersome membrane as a further step toward the design of intelligent multifunctional compartments for use in synthetic biology and as protocells. Host–guest interactions between adamantane and β-cyclodextrin as well as noncovalent interactions between poly(ethylene glycol) tails and β-cyclodextrin are used to achieve selective and dynamic functionalization of the inner and outer spheres of the polymersome membrane.

Involved external institutions

Leibniz-Institut für Polymerforschung Dresden e. V. DE Germany (DE) National Research Centre (NRC) / المركز القومي للبحوث EG Egypt (EG) Universität Basel CH Switzerland (CH)

How to cite

APA:

Iyisan, B., Siedel, A.C., Gumz, H., Yassin, M., Kluge, J., Gaitzsch, J.,... Appelhans, D. (2017). Dynamic Docking and Undocking Processes Addressing Selectively the Outside and Inside of Polymersomes. Macromolecular Rapid Communications, 38(21). https://doi.org/10.1002/marc.201700486

MLA:

Iyisan, Banu, et al. "Dynamic Docking and Undocking Processes Addressing Selectively the Outside and Inside of Polymersomes." Macromolecular Rapid Communications 38.21 (2017).

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