Effects of cardiovascular single pill combinations compared with identical multi-pill therapies on healthcare cost and utilization in Germany

Wilke T, Weisser B, Predel HG, Schmieder R, Wassmann S, Gillessen A, Blettenberg J, Maywald U, Randerath O, Mueller S, Boehm M (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Journal of Comparative Effectiveness Research Future Medicine

Book Volume: 11

Pages Range: 411-422

Journal Issue: 6

DOI: 10.2217/cer-2021-0197

Abstract

Aim: This study assessed whether a single pill combination (SPC) is associated with lower direct healthcare costs. Materials & methods: Anonymized claims data of patients >= 18 years treated with drugs for cardiovascular (CV)-related diseases either as a single pill combination or multi-pill combination (follow-up to 1 year) were evaluated. After propensity score matching, 59,336 out of 1,369,840 patients were analyzed. Results: In all cohorts, patients receiving a single pill combination had a lower frequency of general practitioner and specialist visits. The patients also had a significantly lower ratio of all-cause hospitalization days and number of CV-related prescriptions as well as all-cause prescriptions (with one exception) compared with those receiving a multi-pill combination. Conclusion: Direct CV-related costs were significantly lower in four out of seven comparisons, with a trend toward lower costs in the other three comparisons.

Authors with CRIS profile

Roland Schmieder Professur für Innere Medizin (Nephrologie)

Involved external institutions

Herz-Jesu-Krankenhaus Hiltrup DE Germany (DE) Allgemeine Ortskrankenkasse (AOK) DE Germany (DE) Universität des Saarlandes (UdS) DE Germany (DE) Ingress-Health HWM GmbH DE Germany (DE) Hochschule Wismar, University of Applied Sciences, Technology, Business and Design DE Germany (DE) Christian-Albrechts-Universität zu Kiel DE Germany (DE) Kliniken München Pasing und Perlach DE Germany (DE) Deutsche Sporthochschule Köln DE Germany (DE) APONTIS PHARMA GmbH & Co. KG DE Germany (DE)

How to cite

APA:

Wilke, T., Weisser, B., Predel, H.-G., Schmieder, R., Wassmann, S., Gillessen, A.,... Boehm, M. (2022). Effects of cardiovascular single pill combinations compared with identical multi-pill therapies on healthcare cost and utilization in Germany. Journal of Comparative Effectiveness Research, 11(6), 411-422. https://doi.org/10.2217/cer-2021-0197

MLA:

Wilke, Thomas, et al. "Effects of cardiovascular single pill combinations compared with identical multi-pill therapies on healthcare cost and utilization in Germany." Journal of Comparative Effectiveness Research 11.6 (2022): 411-422.

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