Serum levels of olanzapine are associated with acute cognitive effects in bipolar disorder
Shoshina II, Almeida NL, Oliveira ME, Trombetta BN, Silva GM, Fars J, Santos NA, Fernandes TP (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 310
Article Number: 114443
DOI: 10.1016/j.psychres.2022.114443
Abstract
Bipolar (BPD) patients have deficits in cognition, but there are still controversies about the effects of some medications on their cognitive performance. Here, we investigated the relationship between cognition in terms of executive functions, memory, and attention in both first-episode medication-naive BPD patients and BPD patients taking olanzapine. Forty-one healthy controls, 40 unmedicated drug-naive BPD patients, and 34 BPD patients who took only olanzapine were recruited for the study. Cognitive performance was assessed using the Flanker test, Stroop test, and Corsi-block test. Bayesian multivariate regression analysis was run considering maximum robustness to avoid bias and to predict the outcomes. Our results revealed that unmedicated medication-naive BPD patients performed worse than healthy controls and the olanzapine group in some tasks. Additionally, BPD patients who took olanzapine had better cognitive performance than healthy controls and unmedicated BPD patients. The acute cognitive effects were predicted by olanzapine dosage and serum levels (i.e., large effects). The potential pro-cognitive effects of olanzapine in BPD patients should be carefully interpreted by considering various other clinical variables. We expect that our findings will contribute to further research in this area, with the goal of helping other researchers, patients, and the population.
Authors with CRIS profile
Involved external institutions
Universidade Federal da Paraíba
Brazil (BR)
Pavlov Institute of Physiology of the Russian Academy of Sciences (IP Pavlov, SPbNTs RAS) / Институт физиологии им. И.П. Павлова
Russian Federation (RU)
Brazil (BR)
Pavlov Institute of Physiology of the Russian Academy of Sciences (IP Pavlov, SPbNTs RAS) / Институт физиологии им. И.П. Павлова
Russian Federation (RU)
How to cite
APA:
Shoshina, I.I., Almeida, N.L., Oliveira, M.E., Trombetta, B.N., Silva, G.M., Fars, J.,... Fernandes, T.P. (2022). Serum levels of olanzapine are associated with acute cognitive effects in bipolar disorder. Psychiatry Research, 310. https://dx.doi.org/10.1016/j.psychres.2022.114443
MLA:
Shoshina, Irina I., et al. "Serum levels of olanzapine are associated with acute cognitive effects in bipolar disorder." Psychiatry Research 310 (2022).
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