Antibody cross-reactivity between casein and myelin-associated glycoprotein results in central nervous system demyelination

Chunder R, Weier A, Mäurer H, Luber N, Enders M, Luber G, Heider T, Spitzer A, Tacke S, Becker-Gotot J, Kurts C, Iyer R, Ho PP, Robinson WH, Lanz TV, Kuerten S (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Proceedings of the National Academy of Sciences of the United States of America National Academy of Sciences

Book Volume: 119

Pages Range: e2117034119

Journal Issue: 10

DOI: 10.1073/pnas.2117034119

Abstract

Significance Multiple sclerosis (MS) is the most prevalent autoimmune disease of the central nervous system (CNS), leading to irreversible deficits in young adults. Its pathophysiology is believed to be influenced by environmental determinants. As far back as the 1990s, it had been suggested that there is a correlation between the consumption of cow's milk and the prevalence of MS. Here, we not only demonstrate that a high percentage of MS patients harbor antibodies to bovine casein but also that antibody cross-reactivity between cow's milk and CNS antigens can exacerbate demyelination. Our data broaden the current understanding of how diet influences the etiology of MS and set the stage for combining personalized diet plans with disease-modifying treatment strategies.

Authors with CRIS profile

Hannah Mäurer Lehrstuhl für Mikroskopische Anatomie und Molekulare Zellbiologie Sabine Tacke Lehrstuhl für Mikroskopische Anatomie und Molekulare Zellbiologie Stefanie Kürten

Involved external institutions

Rheinische Friedrich-Wilhelms-Universität Bonn DE Germany (DE) Stanford University US United States (USA) (US) Klinikum St. Marien Amberg DE Germany (DE)

How to cite

APA:

Chunder, R., Weier, A., Mäurer, H., Luber, N., Enders, M., Luber, G.,... Kuerten, S. (2022). Antibody cross-reactivity between casein and myelin-associated glycoprotein results in central nervous system demyelination. Proceedings of the National Academy of Sciences of the United States of America, 119(10), e2117034119. https://dx.doi.org/10.1073/pnas.2117034119

MLA:

Chunder, Rittika, et al. "Antibody cross-reactivity between casein and myelin-associated glycoprotein results in central nervous system demyelination." Proceedings of the National Academy of Sciences of the United States of America 119.10 (2022): e2117034119.

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