Revised German guidelines on the diagnosis and treatment of carcinoma of the uterine cervix-what's new for pathologists in 2021?

Horn LC, Beckmann M, Follmann M, Koch MC, Nothacker M, Poschel B, Stübs F, Schmidt D, Hohn AK (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Pathologe Springer Verlag (Germany)

DOI: 10.1007/s00292-021-01051-3

Abstract

In 2021, the 2015 German consensus guideline for the diagnosis and treatment of uterine cervical carcinoma was updated. The present article summarises the new recommendations for pathologists: the incorporation of the International Endocervical Adenocarcinoma Classification (IECC), which morphologically separates HPV-associated and non-HPV-associated adenocarcinomas, as well as the reporting of the prognostic relevant growth pattern of the adenocarcinoma of the endocervical subtype (Silva pattern). Histologically, multifocality has been defined as the presence of clearly invasive foci with a minimum distance between each focus of 0.2 cm. Because of its intratumoural heterogeneity, all carcinomas <= 2 cm in their largest dimension should be processed completely, and tumours > 2 cm should be processed with one block per centimetre of their greatest dimension. In cases of (radical) trachelectomy/hysterectomy, the distal vaginal resection margin and all parametrial tissue should be processed completely. Sentinel lymph nodes have to be processed completely by lamellation along its long axis in 0.2 cm intervals. Immunohistochemical ultrastaging is mandatory. Staging should be performed using the 2009 FIGO classification and 2017 TNM classification. Reporting the revised 2018 FIGO classification is optional. To date, molecular markers have not been relevant for prognostication and treatment decision making.

Authors with CRIS profile

Matthias Beckmann Lehrstuhl für Geburtshilfe und Frauenheilkunde Frederik Stübs Department of Obstetrics and Gynaecology

Involved external institutions

ANregiomed DE Germany (DE) Universitätsklinikum Leipzig DE Germany (DE) Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e.V. (AWMF) e.V. DE Germany (DE) Deutsche Krebsgesellschaft (DKG) DE Germany (DE)

How to cite

APA:

Horn, L.-C., Beckmann, M., Follmann, M., Koch, M.C., Nothacker, M., Poschel, B.,... Hohn, A.K. (2022). Revised German guidelines on the diagnosis and treatment of carcinoma of the uterine cervix-what's new for pathologists in 2021? Pathologe. https://doi.org/10.1007/s00292-021-01051-3

MLA:

Horn, Lars-Christian, et al. "Revised German guidelines on the diagnosis and treatment of carcinoma of the uterine cervix-what's new for pathologists in 2021?" Pathologe (2022).

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