European patch test results with audit allergens as candidates for inclusion in the European Baseline Series, 2019/20: Joint results of the ESSCAA and the EBSB working groups of the ESCD, and the GEIDACC

Uter W, Wilkinson SM, Aerts O, Bauer A, Borrego L, Buhl T, Cooper SM, Dickel H, Gallo R, Gimenez-Arnau AM, John SM, Navarini AA, Pesonen M, Ponyai G, Rustemeyer T, Schliemann S, Schubert S, Schuttelaar MLA, Valiukeviciene S, Wagner N, Weisshaar E, Goncalo M (2022)

Publication Type: Journal article

Publication year: 2022

Journal

DOI: 10.1111/cod.14059

Abstract

Background: In 2019, a number of allergens (haptens), henceforth, “the audit allergens,” were considered as potential additions to the European Baseline Series (EBS), namely, sodium metabisulfite, 2-bromo-2-nitropropane-1,3-diol, diazolidinyl urea, imidazolidinyl urea, Compositae mix II (2.5% or 5% pet), linalool hydroperoxides (lin-OOH), limonene hydroperoxides (lim-OOH), benzisothiazolinone (BIT), octylisothiazolinone (OIT), decyl glucoside, and lauryl glucoside; Evernia furfuracea (tree moss), was additionally tested by some departments as well. Objectives: To collect further data on patch test reactivity and clinical relevance of the audit allergens in consecutive patients across Europe. Methods: Patch test data covering the audit allergens in 2019 and 2020 were collected by those departments of the European Surveillance System on Contact Allergies testing these, as well as further collaborators from the EBS working group of the European Society of Contact Dermatitis (ESCD), and the Spanish Grupo Español de Investigación en Dermatitis de Contacto y Alergia Cutánea. As patch test outcome, reactions between day (D) 3 and D5 were considered. Results: Altogether n = 12 403 patients were tested with any of the audit allergen. Positive reactions were most common to lin-OOH 1% pet. (8.74% [95%CI: 8.14–9.37%]), followed by lin-OOH 0.5% pet., and lim-OOH 0.3% pet (5.41% [95% CI: 4.95–5.89%]). Beyond these terpene hydroperoxides, BIT 0.1% pet. was the second most common allergen with 4.72% (95% CI: 4.2–5.28%), followed by sodium metabisulfite 1% pet. (3.75% [95%CI: 3.32–4.23%]) and Compositae mix 5% pet. (2.31% [95% CI: 1.84–2.87%]). For some allergens, clinical relevance was frequently difficult to ascertain. Conclusions: Despite many positive patch test reactions, it remains controversial whether lin- and lim-OOH should be tested routinely, while at least the two preservatives BIT and sodium metabisulfite appear suitable. The present results are a basis for further discussion and ultimately decision on their implementation into routine testing among the ESCD members.

Authors with CRIS profile

Involved external institutions

Technische Universität Dresden Germany (DE) Oxford University Hospitals NHS Foundation Trust United Kingdom (GB) Universität Osnabrück Germany (DE) Semmelweis University / Semmelweis Egyetem Hungary (HU) Universitätsklinikum Jena Germany (DE) University of Groningen / Rijksuniversiteit Groningen Netherlands (NL) University of Antwerp / Universiteit Antwerpen Belgium (BE) Finnish Institute of Occupational Health (FIOH) / Työterveyslaitos (TTL) Finland (FI) Universitätsspital Basel Switzerland (CH) Universidade de Coimbra Portugal (PT) Amsterdam University Medical Centers (Amsterdam UMC) / Amsterdam Universitair Medische Centra Netherlands (NL) Universidad de Las Palmas Gran Canaria Spain (ES) Autonomous University of Barcelona (UAB) / Universitat Autònoma de Barcelona Spain (ES) Universitätsklinikum Heidelberg Germany (DE) University of Genova / Università degli Studi di Genova Italy (IT) Lithuanian University of Health Sciences / Lietuvos sveikatos mokslų universitetas (LSMU) Lithuania (LT) Universitätsklinikum Göttingen Germany (DE) Georg-August-Universität Göttingen Germany (DE) Ruhr-Universität Bochum (RUB) Germany (DE) Leeds Teaching Hospitals NHS Trust United Kingdom (GB)

How to cite

APA:

Uter, W., Wilkinson, S.M., Aerts, O., Bauer, A., Borrego, L., Buhl, T.,... Goncalo, M. (2022). European patch test results with audit allergens as candidates for inclusion in the European Baseline Series, 2019/20: Joint results of the ESSCAA and the EBSB working groups of the ESCD, and the GEIDACC. Contact Dermatitis. https://doi.org/10.1111/cod.14059

MLA:

Uter, Wolfgang, et al. "European patch test results with audit allergens as candidates for inclusion in the European Baseline Series, 2019/20: Joint results of the ESSCAA and the EBSB working groups of the ESCD, and the GEIDACC." Contact Dermatitis (2022).

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