Prognostic markers in invasive bladder cancer: FGFR3 mutation status versus P53 and KI-67 expression: a multi-center, multi-laboratory analysis in 1058 radical cystectomy patients

Mertens LS, Claps F, Mayr R, Bostrom PJ, Shariat SF, Zwarthoff EC, Boormans JL, Abas C, van Leenders GJ, Götz S, Hippe K, Bertz S, Neuzillet Y, Sanders J, Broeks A, Peters D, van der Heijden MS, Jewett MA, Stöhr R, Zlotta AR, Eckstein M, Soorojebally Y, van der Schoot DK, Wullich B, Burger M, Otto W, Radvanyi F, Sirab N, Pouessel D, van der Kwast TH, Hartmann A, Lotan Y, Allory Y, Zuiverloon TCM, van Rhijn BWG (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Book Volume: 40

Pages Range: 110.e1-110.e9

Journal Issue: 3

DOI: 10.1016/j.urolonc.2021.10.010

Abstract

Objectives: To determine the association between the FGFR3 mutation status and immuno-histochemistry (IHC) markers (p53 and Ki-67) in invasive bladder cancer (BC), and to analyze their prognostic value in a multicenter, multi-laboratory radical cystectomy (RC) cohort. Patients and methods: We included 1058 cN0M0, chemotherapy-naive BC patients who underwent RC with pelvic lymph-node dissection at 8 hospitals. The specimens were reviewed by uro-pathologists. Mutations in the FGFR3 gene were examined using PCR-SNaPshot; p53 and Ki-67 expression were determined by standard IHC. FGFR3 mutation status as well as p53 (cut-off>10%) and Ki-67 (cut-off>20%) expression were correlated to clinicopathological parameters and disease specific survival (DSS). Results: pT-stage was

Authors with CRIS profile

Involved external institutions

University of Texas Southwestern Medical Center (UT Southwestern) United States (USA) (US) University of Toronto Canada (CA) Institut Curie France (FR) Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI / NKI-AVL) Netherlands (NL) Universität Regensburg Germany (DE) Université Fédérale de Toulouse Midi-Pyrénées France (FR) Amphia Ziekenhuis Netherlands (NL) Universitätsklinikum Regensburg Germany (DE) Erasmus University Medical Center (MC) Netherlands (NL)

How to cite

APA:

Mertens, L.S., Claps, F., Mayr, R., Bostrom, P.J., Shariat, S.F., Zwarthoff, E.C.,... van Rhijn, B.W.G. (2022). Prognostic markers in invasive bladder cancer: FGFR3 mutation status versus P53 and KI-67 expression: a multi-center, multi-laboratory analysis in 1058 radical cystectomy patients. Urologic Oncology-Seminars and Original Investigations, 40(3), 110.e1-110.e9. https://doi.org/10.1016/j.urolonc.2021.10.010

MLA:

Mertens, Laura S., et al. "Prognostic markers in invasive bladder cancer: FGFR3 mutation status versus P53 and KI-67 expression: a multi-center, multi-laboratory analysis in 1058 radical cystectomy patients." Urologic Oncology-Seminars and Original Investigations 40.3 (2022): 110.e1-110.e9.

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