Latest knowledge about changes in the proteome in microgravity

Schulz H, Strauch SM, Richter P, Wehland M, Krueger M, Sahana J, Corydon TJ, Wise P, Baran R, Lebert M, Grimm D (2022)

Publication Type: Journal article, Review article

Publication year: 2022


DOI: 10.1080/14789450.2022.2030711


Introduction A long-term stay of humans in space causes health problems and changes in protists and plants. Deep space exploration will increase the time humans or rodents will spend in microgravity (mu g). Moreover, they are exposed to cosmic radiation, hypodynamia, and isolation. OMICS investigations will increase our knowledge of the underlying mechanisms of mu g-induced alterations in vivo and in vitro. Areas covered We summarize the findings over the recent 3 years on mu g-induced changes in the proteome of protists, plants, rodent, and human cells. Considering the thematic orientation of microgravity-related publications in that time frame, we focus on medicine-associated findings, such as the mu g-induced antibiotic resistance of bacteria, the myocardial consequences of mu g-induced calpain activation, and the role of MMP13 in osteoarthritis. All these point to the fact that mu g is an extreme stressor that could not be evolutionarily addressed on Earth. Expert opinion In conclusion, when interpreting mu g-experiments, the direct, mostly unspecific stress response, must be distinguished from specific mu g-effects. For this reason, recent studies often do not consider single protein findings but place them in the context of protein-protein interactions. This enables an estimation of functional relationships, especially if these are supported by epigenetic and transcriptional data (multi-omics).

Authors with CRIS profile

Involved external institutions

How to cite


Schulz, H., Strauch, S.M., Richter, P., Wehland, M., Krueger, M., Sahana, J.,... Grimm, D. (2022). Latest knowledge about changes in the proteome in microgravity. Expert Review of Proteomics.


Schulz, Herbert, et al. "Latest knowledge about changes in the proteome in microgravity." Expert Review of Proteomics (2022).

BibTeX: Download