Lima1 mediates the pluripotency control of membrane dynamics and cellular metabolism

Duethorn B, Groll F, Rieger B, Drexler HCA, Brinkmann H, Kremer L, Stehling M, Borowski MT, Mildner K, Zeuschner D, Zernicka-Goetz M, Stemmler M, Busch KB, Vaquerizas JM, Bedzhov I (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Nature Communications Nature Publishing Group: Nature Communications

Book Volume: 13

Pages Range: 610-

Journal Issue: 1

DOI: 10.1038/s41467-022-28139-5

Abstract

Lima1 is an extensively studied prognostic marker of malignancy and is also considered to be a tumour suppressor, but its role in a developmental context of non-transformed cells is poorly understood. Here, we characterise the expression pattern and examined the function of Lima1 in mouse embryos and pluripotent stem cell lines. We identify that Lima1 expression is controlled by the naïve pluripotency circuit and is required for the suppression of membrane blebbing, as well as for proper mitochondrial energetics in embryonic stem cells. Moreover, forcing Lima1 expression enables primed mouse and human pluripotent stem cells to be incorporated into murine pre-implantation embryos. Thus, Lima1 is a key effector molecule that mediates the pluripotency control of membrane dynamics and cellular metabolism.

Authors with CRIS profile

Marc Stemmler Lehrstuhl für Experimentelle Medizin mit dem Schwerpunkt Molekulare Pathogeneseforschung

Involved external institutions

Max-Planck-Institut für molekulare Biomedizin / Max Planck Institute for Molecular Biomedicine DE Germany (DE) University of Cambridge GB United Kingdom (GB) Westfälische Wilhelms-Universität (WWU) Münster DE Germany (DE)

How to cite

APA:

Duethorn, B., Groll, F., Rieger, B., Drexler, H.C.A., Brinkmann, H., Kremer, L.,... Bedzhov, I. (2022). Lima1 mediates the pluripotency control of membrane dynamics and cellular metabolism. Nature Communications, 13(1), 610-. https://dx.doi.org/10.1038/s41467-022-28139-5

MLA:

Duethorn, Binyamin, et al. "Lima1 mediates the pluripotency control of membrane dynamics and cellular metabolism." Nature Communications 13.1 (2022): 610-.

BibTeX: Download