Plasma renin and aldosterone concentrations related to endovascular ultrasound renal denervation in the RADIANCE-HTN SOLO trial
Fisher ND, Kirtane AJ, Daemen J, Rader F, Lobo MD, Saxena M, Abraham J, Schmieder R, Sharp AS, Gosse P, Claude L, Song Y, Azizi M (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 40
Pages Range: 221-228
Journal Issue: 2
DOI: 10.1097/HJH.0000000000002994
Abstract
Objective: The RADIANCE-HTN SOLO trial demonstrated a greater reduction in daytime ambulatory SBP at 2 months by endovascular ultrasound renal denervation than sham procedure. We hypothesized that plasma renin and aldosterone concentrations would be associated with the SBP response to renal denervation. Methods: Hypertensive patients were randomized to renal denervation (n=74) or sham (n=72) after a 4-week washout of antihypertensive medications. In a 53-patient subset, 2-month and 6-month plasma renin and aldosterone concentration were measured. Dietary sodium was not controlled. Results: Mean age of the 29 treatment and 24 sham patients was 54years; 62% were men; 17% black. Daytime ambulatory SBP fell in the denervation but not the sham group at 2 months (-7.8=10.7 vs. -0.1=10.1mmHg; P=0.048). Baseline plasma renin and aldosterone concentrations were in the low-normal range, did not change significantly at 2 months in either group and did not predict response to renal denervation. At 6 months, after the addition of antihypertensive medications, there was a significant rise in renin in the sham but not the denervation group. Conclusion: Although renal denervation but not sham resulted in a decrease in daytime ambulatory SBP at 2 months, renin and aldosterone concentrations did neither predict the BP response to renal denervation; nor did they fall after denervation. A rise in renin at 6 months in the sham group likely represents confounding from antihypertensive medications. Whether the BP-lowering effect of renal denervation depends on reducing local intrarenal renin release requires further study.
Authors with CRIS profile
Involved external institutions
Columbia University Irving Medical Center (CUIMC)
United States (USA) (US)
Veterans Affairs Healthcare System Boston and Harvard Medical School
United States (USA) (US)
Erasmus University Medical Center (MC)
Netherlands (NL)
Cedars-Sinai Medical Center
United States (USA) (US)
Queen Mary, University of London
United Kingdom (GB)
University of Utah
United States (USA) (US)
University Hospital of Wales (UHW)
United Kingdom (GB)
Centre Hospitalier Universitaire de Bordeaux / CHU Bordeaux
France (FR)
Baim Institute for Clinical Research
United States (USA) (US)
Université de Paris
France (FR)
United States (USA) (US)
Veterans Affairs Healthcare System Boston and Harvard Medical School
United States (USA) (US)
Erasmus University Medical Center (MC)
Netherlands (NL)
Cedars-Sinai Medical Center
United States (USA) (US)
Queen Mary, University of London
United Kingdom (GB)
University of Utah
United States (USA) (US)
University Hospital of Wales (UHW)
United Kingdom (GB)
Centre Hospitalier Universitaire de Bordeaux / CHU Bordeaux
France (FR)
Baim Institute for Clinical Research
United States (USA) (US)
Université de Paris
France (FR)
How to cite
APA:
Fisher, N.D., Kirtane, A.J., Daemen, J., Rader, F., Lobo, M.D., Saxena, M.,... Azizi, M. (2022). Plasma renin and aldosterone concentrations related to endovascular ultrasound renal denervation in the RADIANCE-HTN SOLO trial. Journal of Hypertension, 40(2), 221-228. https://doi.org/10.1097/HJH.0000000000002994
MLA:
Fisher, Naomi D.L., et al. "Plasma renin and aldosterone concentrations related to endovascular ultrasound renal denervation in the RADIANCE-HTN SOLO trial." Journal of Hypertension 40.2 (2022): 221-228.
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