Pregnant and Postpartum Women Requiring Intensive Care Treatment for COVID-19—First Data from the CRONOS-Registry

Sitter M, Pecks U, Rüdiger M, Friedrich S, Malfertheiner SF, Hein A, Königbauer JT, Becke-Jakob K, Zöllkau J, Ramsauer B, Rathberger K, Pontones C, Kraft K, Meybohm P, Härtel C, Kranke P (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Journal of Clinical Medicine MDPI

Book Volume: 11

Article Number: 701

Journal Issue: 3

DOI: 10.3390/jcm11030701

Abstract

(1) Background: Data on coronavirus 2 infection during pregnancy vary. We aimed to describe maternal characteristics and clinical presentation of SARS-CoV-2 positive women requiring intensive care treatment for COVID-19 during pregnancy and postpartum period based on data of a comprehensive German surveillance system in obstetric patients. (2) Methods: Data from COVID-19 Related Obstetric and Neonatal Outcome Study (CRONOS), a prospective multicenter registry for SARS-CoV-2 positive pregnant women, was analyzed with respect to ICU treatment. All women requiring intensive care treatment for COVID-19 were included and compared regarding maternal characteristics, course of disease, as well as maternal and neonatal outcomes. (3) Results: Of 2650 cases in CRONOS, 101 women (4%) had a documented ICU stay. Median maternal age was 33 (IQR, 30–36) years. COVID-19 was diagnosed at a median gestational age of 33 (IQR, 28–35) weeks. As the most invasive form of COVID-19 treatment interventions, patients received either continuous monitoring of vital signs without further treatment requirement (n = 6), insufflation of oxygen (n = 30), non-invasive ventilation (n = 22), invasive ventilation (n = 28), or escalation to extracorporeal membrane oxygenation (n = 15). No significant clinical differences were identified between patients receiving different forms of ventilatory support for COVID-19. Prevalence of preterm delivery was significantly higher in women receiving invasive respiratory treatments. Four women died of COVID-19 and six fetuses were stillborn. (4) Conclusions: Our cohort shows that progression of COVID-19 is rare in pregnant and postpartum women treated in the ICU. Preterm birth rate is high and COVID-19 requiring respiratory support increases the risk of poor maternal and neonatal outcome.

Authors with CRIS profile

Alexander Hein Department of Obstetrics and Gynaecology Constanza Pontones Department of Obstetrics and Gynaecology

Involved external institutions

Universitätsklinikum Würzburg DE Germany (DE) Universitätsklinikum Schleswig-Holstein (UKSH) DE Germany (DE) Universitätsklinikum Carl Gustav Carus Dresden DE Germany (DE) Universitätsklinikum Regensburg DE Germany (DE) Vivantes - Netzwerk für Gesundheit GmbH DE Germany (DE) Cnopf'sche Kinderklinik DE Germany (DE) Universitätsklinikum Jena DE Germany (DE) München Klinik gGmbH DE Germany (DE)

How to cite

APA:

Sitter, M., Pecks, U., Rüdiger, M., Friedrich, S., Malfertheiner, S.F., Hein, A.,... Kranke, P. (2022). Pregnant and Postpartum Women Requiring Intensive Care Treatment for COVID-19—First Data from the CRONOS-Registry. Journal of Clinical Medicine, 11(3). https://doi.org/10.3390/jcm11030701

MLA:

Sitter, Magdalena, et al. "Pregnant and Postpartum Women Requiring Intensive Care Treatment for COVID-19—First Data from the CRONOS-Registry." Journal of Clinical Medicine 11.3 (2022).

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