Targeted Therapy, Chemotherapy, Immunotherapy and Novel Treatment Options for Different Subtypes of Salivary Gland Cancer

Mueller SK, Haderlein M, Lettmaier S, Agaimy A, Haller F, Hecht M, Fietkau R, Iro H, Mantsopoulos K (2022)

Publication Type: Journal article, Review article

Publication year: 2022

Journal

Journal of Clinical Medicine MDPI

Book Volume: 11

Article Number: 720

Journal Issue: 3

DOI: 10.3390/jcm11030720

Abstract

Surgical resection remains the first line treatment for salivary gland cancer (SGC). In the case of locally advanced disease, surgery is followed by adjuvant radiotherapy. Surgical resection should be favored in resectable locoregional recurrent disease as well, and even the complete resection of all distant oligometastases has clinical benefit for the patients. For inoperable and disseminated metastatic disease, a multitude of systemic therapies including chemotherapy, targeted therapy, and immunotherapy are available. In this review, the current therapeutic options for inoperable recurrent or metastatic SGCs are summarized. Systemic treatment can achieve prolonged progression-free and overall survival, while the overall prognosis remains poor. Current clinical trials include only a limited number of patients and mostly combine different histologic subtypes. Additionally, no randomized controlled trial comparing different therapeutic options has been performed. In the future, further studies with a larger patient cohort and ideally only one histologic subtype are needed in order to improve the outcome for SGC patients. However, this may be difficult to accomplish due to the rarity and diversity of the disease. Additionally, molecular analyses need to be performed routinely in order to individualize treatment and to go one step further towards precision medicine.

Authors with CRIS profile

Sarina Müller-Hübner Department of Otorhinolaryngology – Head and Neck Surgery Marlen Haderlein Department of Radiation Oncology Abbas Agaimy Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Florian Haller Professur für Diagnostische Molekularpathologie Markus Hecht Department of Radiation Oncology Rainer Fietkau Lehrstuhl für Strahlentherapie Heinrich Iro Lehrstuhl für Hals-, Nasen- und Ohrenheilkunde Konstantinos Mantsopoulos Department of Otorhinolaryngology – Head and Neck Surgery

How to cite

APA:

Mueller, S.K., Haderlein, M., Lettmaier, S., Agaimy, A., Haller, F., Hecht, M.,... Mantsopoulos, K. (2022). Targeted Therapy, Chemotherapy, Immunotherapy and Novel Treatment Options for Different Subtypes of Salivary Gland Cancer. Journal of Clinical Medicine, 11(3). https://doi.org/10.3390/jcm11030720

MLA:

Mueller, Sarina K., et al. "Targeted Therapy, Chemotherapy, Immunotherapy and Novel Treatment Options for Different Subtypes of Salivary Gland Cancer." Journal of Clinical Medicine 11.3 (2022).

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