No evidence for increased cell entry or antibody evasion by Delta sublineage AY.4.2

Arora P, Kempf A, Nehlmeier I, Graichen L, Winkler MS, Lier M, Schulz S, Jäck HM, Poehlmann S, Hoffmann M (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Cellular & Molecular Immunology Nature Publishing Group: Open Access Hybrid Model Option A

DOI: 10.1038/s41423-021-00811-8

Abstract

Since the beginning of the COVID-19 pandemic, multiple SARS-CoV-2 variants have emerged. While some variants spread only locally, others, referred to as variants of concern, disseminated globally and became drivers of the pandemic. All SARS-CoV-2 variants harbor mutations relative to the virus circulating early in the pandemic, and mutations in the viral spike (S) protein are considered of particular relevance since the S protein mediates host cell entry and constitutes the key target of the neutralizing antibody response. As a consequence, mutations in the S protein may increase SARS-CoV-2 infectivity and enable its evasion of neutralizing antibodies. Furthermore, mutations in the S protein can modulate viral transmissibility and pathogenicity.

Authors with CRIS profile

Sebastian Schulz Professur für Immunologie Hans-Martin Jäck Department of Molecular Immunology

Involved external institutions

Deutsches Primatenzentrum (DPZ), Leibniz-Institut für Primatenforschung DE Germany (DE) Georg-August-Universität Göttingen DE Germany (DE)

How to cite

APA:

Arora, P., Kempf, A., Nehlmeier, I., Graichen, L., Winkler, M.S., Lier, M.,... Hoffmann, M. (2022). No evidence for increased cell entry or antibody evasion by Delta sublineage AY.4.2. Cellular & Molecular Immunology. https://doi.org/10.1038/s41423-021-00811-8

MLA:

Arora, Prerna, et al. "No evidence for increased cell entry or antibody evasion by Delta sublineage AY.4.2." Cellular & Molecular Immunology (2022).

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