Unraveling energy homeostasis in a dynamic model of glycolysis in Escherichia coli
Giordano G, De Graaf LM, Vasilakou E, Wahl SA (2019)
Publication Type: Conference contribution
Publication year: 2019
Publisher: Institute of Electrical and Electronics Engineers Inc.
Pages Range: 2140-2145
Conference Proceedings Title: 2019 18th European Control Conference, ECC 2019
Event location: Naples
ISBN: 9783907144008
DOI: 10.23919/ECC.2019.8795884
Abstract
We study dynamic metabolic models that describe the cellular responses of microorganisms under changing environmental conditions, such as substrate perturbations. Feast-famine experiments in Escherichia coli show that, despite the enormous extracellular perturbations, important quantities such as the cell energy charge remain practically constant. We propose a simplified kinetic model of glycolysis in E. coli and we analyse it to investigate the mechanisms that guarantee the observed homeostatic energy charge. Identifying the source of this extraordinary robustness will streamline the synthesis of robust and efficient 'cell factories' for the production of relevant chemicals, enabling sustainable processes.
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APA:
Giordano, G., De Graaf, L.M., Vasilakou, E., & Wahl, S.A. (2019). Unraveling energy homeostasis in a dynamic model of glycolysis in Escherichia coli. In 2019 18th European Control Conference, ECC 2019 (pp. 2140-2145). Naples, IT: Institute of Electrical and Electronics Engineers Inc..
MLA:
Giordano, Giulia, et al. "Unraveling energy homeostasis in a dynamic model of glycolysis in Escherichia coli." Proceedings of the 18th European Control Conference, ECC 2019, Naples Institute of Electrical and Electronics Engineers Inc., 2019. 2140-2145.
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