Consensus on diagnosis and management of Cushing's disease: a guideline update

Fleseriu M, Auchus R, Bancos I, Ben-Shlomo A, Bertherat J, Biermasz NR, Boguszewski CL, Bronstein MD, Buchfelder M, Carmichael JD, Casanueva FF, Castinetti F, Chanson P, Findling J, Gadelha M, Geer EB, Giustina A, Grossman A, Gurnell M, Ho K, Ioachimescu AG, Kaiser UB, Karavitaki N, Katznelson L, Kelly DF, Lacroix A, Mccormack A, Melmed S, Molitch M, Mortini P, Newell-Price J, Nieman L, Pereira AM, Petersenn S, Pivonello R, Raff H, Reincke M, Salvatori R, Scaroni C, Shimon I, Stratakis CA, Swearingen B, Tabarin A, Takahashi Y, Theodoropoulou M, Tsagarakis S, Valassi E, Varlamov EV, Vila G, Wass J, Webb SM, Zatelli MC, Biller BMK (2021)

Publication Type: Journal article, Review article

Publication year: 2021

Journal

Book Volume: 9

Pages Range: 847-875

Journal Issue: 12

DOI: 10.1016/S2213-8587(21)00235-7

Abstract

Cushing's disease requires accurate diagnosis, careful treatment selection, and long-term management to optimise patient outcomes. The Pituitary Society convened a consensus workshop comprising more than 50 academic researchers and clinical experts to discuss the application of recent evidence to clinical practice. In advance of the virtual meeting, data from 2015 to present about screening and diagnosis; surgery, medical, and radiation therapy; and disease-related and treatment-related complications of Cushing's disease summarised in recorded lectures were reviewed by all participants. During the meeting, concise summaries of the recorded lectures were presented, followed by small group breakout discussions. Consensus opinions from each group were collated into a draft document, which was reviewed and approved by all participants. Recommendations regarding use of laboratory tests, imaging, and treatment options are presented, along with algorithms for diagnosis of Cushing's syndrome and management of Cushing's disease. Topics considered most important to address in future research are also identified.

Authors with CRIS profile

Involved external institutions

Pacific Neuroscience Institute (PNI) United States (USA) (US) Université de Montréal Canada (CA) Garvan Institute of Medical Research Australia (AU) Cedars-Sinai Medical Center United States (USA) (US) Northwestern University United States (USA) (US) Università Vita-Salute San Raffaele (UniSR) Italy (IT) University of Sheffield United Kingdom (GB) US National Institutes of Health (NIH) United States (USA) (US) Leiden University Medical Center Netherlands (NL) ENDOC Praxis für Endokrinologie, Andrologie und medikamentöse Tumortherapie Germany (DE) Università degli Studi di Napoli Federico II Italy (IT) Medical College of Wisconsin (MCW) United States (USA) (US) Ludwig-Maximilians-Universität (LMU) Germany (DE) Johns Hopkins University (JHU) United States (USA) (US) University of Padua / Universita degli Studi di Padova Italy (IT) Emory University United States (USA) (US) Rabin Medical Center / מרכז רפואי רבין‎‎ Israel (IL) Massachusetts General Hospital United States (USA) (US) Oregon Health and Science University (OSHU) United States (USA) (US) University of Michigan United States (USA) (US) Mayo Clinic United States (USA) (US) University of Paris 4 - Paris-Sorbonne / Université paris IV Paris-Sorbonne France (FR) Universidade Federal do Paraná (UFPR) Brazil (BR) University of São Paulo / Universidade de São Paulo (USP) Brazil (BR) University of Southern California (USC) United States (USA) (US) University of Santiago de Compostela / Universidad de Santiago de Compostela (USC) Spain (ES) Aix-Marseille University / Aix-Marseille Université France (FR) École Polytechnique - Université Paris-Saclay France (FR) Universidade Federal do Rio de Janeiro (UFRJ) / Federal University of Rio de Janeiro Brazil (BR) Memorial Sloan Kettering Cancer Center United States (USA) (US) University College London (UCL) United Kingdom (GB) University of Cambridge United Kingdom (GB) Brigham and Women's Hospital (BWH) United States (USA) (US) University of Birmingham United Kingdom (GB) Stanford University United States (USA) (US) Institut national de physique nucléaire et de physique des particules (IN2P3) France (FR) Nara Medical University Japan (JP) Evangelismos Medical Center Greece (GR) Hospital General de Catalunya Spain (ES) Medizinische Universität Wien Austria (AT) Oxford University Hospitals NHS Foundation Trust United Kingdom (GB) Hospital de la Santa Creu i Sant Pau Spain (ES) Università degli Studi di Ferrara Italy (IT)

How to cite

APA:

Fleseriu, M., Auchus, R., Bancos, I., Ben-Shlomo, A., Bertherat, J., Biermasz, N.R.,... Biller, B.M.K. (2021). Consensus on diagnosis and management of Cushing's disease: a guideline update. Lancet Diabetes and Endocrinology, 9(12), 847-875. https://doi.org/10.1016/S2213-8587(21)00235-7

MLA:

Fleseriu, Maria, et al. "Consensus on diagnosis and management of Cushing's disease: a guideline update." Lancet Diabetes and Endocrinology 9.12 (2021): 847-875.

BibTeX: Download