THE USE OF BOLUS IN POSTMASTECTOMY RADIATION THERAPY FOR BREAST CANCER: A SYSTEMATIC REVIEW

Dahn H, Boersma L, De Ruysscher D, Meattini I, Offersen B, Pignol JP, Belkacemi Y, Benjamin D, Bese N, Coles C, Franco P, Ho A, Hol S, Jagsi R, Kirby A, Marrazzo L, Marta G, Moran M, Nichol A, Nissen HD, Strnad V, Zissiadis Y, Aristei C, Poortman P, Kaidar-Person O (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Publisher: ELSEVIER IRELAND LTD

City/Town: CLARE

Pages Range: S38-S38

Conference Proceedings Title: RADIOTHERAPY AND ONCOLOGY

DOI: 10.1016/S0167-8140(21)08963-5

Abstract

Purpose

Post mastectomy radiation therapy (PMRT) reduces locoregional recurrence (LRR) and breast cancer mortality for selected patients. Bolus overcomes the skin-sparing effect of external-beam radiotherapy, ensuring adequate dose to superficial regions at risk of local recurrence (LR). This systematic review summarizes the current evidence regarding the impact of bolus on LR and acute toxicity in the setting of PMRT.
Results

27 studies were included. The use of bolus led to higher rates of acute grade 3 radiation dermatitis (pooled rates of 9.6% with bolus vs. 1.2% without). Pooled crude LR rates from thirteen studies (n = 3756) were similar with (3.5%) and without (3.6%) bolus.
Conclusions

Bolus may be indicated in cases with a high risk of LR in the skin, but seems not to be necessary for all patients. Further work is needed to define the role of bolus in PMRT.

Authors with CRIS profile

Involved external institutions

Royal Marsden Hospital / The Royal Marsden NHS Foundation Trust United Kingdom (GB) Careggi University Hospital / Azienda Ospedaliero Universitaria Careggi Italy (IT) Azienda ospedaliero-universitaria Maggiore della Carità di Novara / University Hospital Maggiore della Carita Italy (IT) GenesisCare Australia (AU) Dalhousie University Canada (CA) Chaim Sheba Medical Center at Tel HaShomer / המרכז הרפואי עש חיים שיבא – תל השומר‎‎ Israel (IL) Maastricht University Netherlands (NL) Paris-Est Créteil University / Université Paris-Est Créteil Val-de-Marne (UPEC) / Université Paris XII-Val-de-Marne / University Paris 12 Marne la Vallée France (FR) Aarhus University Hospital / Aarhus Universitetshospital Denmark (DK) Massachusetts General Hospital United States (USA) (US) University of Cambridge United Kingdom (GB) Acibadem Maslak Hospital / Acıbadem Maslak Hospital Turkey (TR) Yale University United States (USA) (US) British Columbia Cancer Agency Canada (CA) Vejle Sygehus Denmark (DK) Dr. Bernard Verbeeten Instituut Netherlands (NL) Hospital Sírio-Libanês Brazil (BR) University of Antwerp / Universiteit Antwerpen Belgium (BE)

How to cite

APA:

Dahn, H., Boersma, L., De Ruysscher, D., Meattini, I., Offersen, B., Pignol, J.-P.,... Kaidar-Person, O. (2021). THE USE OF BOLUS IN POSTMASTECTOMY RADIATION THERAPY FOR BREAST CANCER: A SYSTEMATIC REVIEW. Radiotherapy and Oncology, S38-S38. https://dx.doi.org/10.1016/S0167-8140(21)08963-5

MLA:

Dahn, Hannah, et al. "THE USE OF BOLUS IN POSTMASTECTOMY RADIATION THERAPY FOR BREAST CANCER: A SYSTEMATIC REVIEW." Radiotherapy and Oncology (2021): S38-S38.

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