High Prevalence of Genital Human Papillomavirus Infection in Patients With Primary Immunodeficiencies
Gernert M, Kiesel M, Froehlich M, Renner R, Strunz PP, Portegys J, Tony HP, Schmalzing M, Schwaneck EC (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 12
DOI: 10.3389/fimmu.2021.789345
Abstract
BackgroundGenital human papillomavirus (HPV)-infections are common in the general population and are responsible for relevant numbers of epithelial malignancies. Much data on the HPV-prevalence is available for secondary immunodeficiencies, especially for patients with human immunodeficiency virus (HIV)-infection. Little is known about the genital HPV-prevalence in patients with primary immunodeficiencies (PIDs). MethodsWe performed a cross-sectional study of patients with PIDs and took genital swabs from male and female patients, which were analyzed with polymerase chain reaction for the presence of HPV-DNA. Clinical and laboratory data was collected to identify risk factors. Results28 PID patients were included in this study. 10 of 28 (35.7%) had HPV-DNA in their genital swabs. 6 patients had high-risk HPV-types (21.4%). Most patients had asymptomatic HPV-infections, as genital warts were rare (2 of 28 patients) and HPV-associated malignancy was absent. Differences in the HPV-positivity regarding clinical PID-diagnosis, duration of PID, age, sex, immunosuppression, immunoglobulin replacement, or circumcision in males were not present. HPV-positive PID patients had higher numbers of T cells (CD3(+)), of cytotoxic T cells (CD3(+)/CD8(+)), of transitional B cells (CD19(+)/CD38(++)/CD10(+)/IgD(+)), and of plasmablasts (CD19(+)/CD38(+)/CD27(++)/IgD(-)) compared to HPV-negative. ConclusionPID patients exhibit a high rate of genital HPV-infections with a high rate of high-risk HPV-types. Regular screening for symptomatic genital HPV-infection and HPV-associated malignancy in PID patients seems recommendable.
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Germany (DE)How to cite
APA:
Gernert, M., Kiesel, M., Froehlich, M., Renner, R., Strunz, P.-P., Portegys, J.,... Schwaneck, E.C. (2021). High Prevalence of Genital Human Papillomavirus Infection in Patients With Primary Immunodeficiencies. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.789345
MLA:
Gernert, Michael, et al. "High Prevalence of Genital Human Papillomavirus Infection in Patients With Primary Immunodeficiencies." Frontiers in Immunology 12 (2021).
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