IL-6 Quotient (The Ratio of Cerebrospinal Fluid IL-6 to Serum IL-6) as a Biomarker of an Unruptured Intracranial Aneurysm

Kaminska J, Dymicka-Piekarska V, Chrzanowski R, Sawicki K, Milewska AJ, Zinczuk J, Tylicka M, Jadeszko M, Mariak Z, Kratz EM, Matowicka-Karna J, Kornhuber J, Lewczuk P, Koper-Lenkiewicz OM (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Journal of Inflammation Research Dove Medical Press

Book Volume: 14

Pages Range: 6103-6114

DOI: 10.2147/JIR.S335618

Abstract

Background: Studies conducted so far have focused mainly on the assessment of IL-6 levels in patients with ruptured brain aneurysms. Carrying out detailed studies in patients with un-ruptured brain aneurysms (UIA) would be extremely important, as it would answer the question of whether IL-6 plays also a role in primary aneurysm formation and growth. Methods: IL-6, S100, NSE, and albumin concentrations in 67 UIA patients and 17 individuals without vascular lesions in the brain were tested using in vitro diagnostic immunoassays according to the manufacturers' instructions. IL-6 Quotient was calculated by dividing cerebrospinal fluid (CSF) IL-6 by serum IL-6. Results: We showed that IL-6 Quotient was significantly higher in UIA patients (1.78) compared to the control group (0.87; p<0.001). Multivariate logistic regression analysis demonstrated that a growth in IL-6 Quotient increases the probability of UIA diagnosis. In UIA patients CSF IL-6 concentration was significantly higher (4.55 pg/ml) compared to the serum concentration (2.39 pg/ml; p<0.001). In both the study and control group, the bloodbrain barrier was intact, thus the CSF-blood gradient of the IL-6 concentration in UIA patients was likely to be the expression of local synthesis of the cytokine within the central nervous system. Patients with multiple brain aneurysms had significantly higher CSF IL-6 levels (5.08 pg/ml) compared to individuals with a single aneurysm (4.14 pg/ml; p=0.0227). Conclusion: This totality of the may suggest IL-6 as a biomarker for UIA formation; however, further studies are needed to unequivocally confirm clinical application of IL-6 concentration evaluation.

Authors with CRIS profile

Johannes Kornhuber Lehrstuhl für Psychiatrie und Psychotherapie Piotr Lewczuk Medizinische Fakultät

Involved external institutions

University of Białystok PL Poland (PL) Wrocław Medical University / Uniwersytet Medyczny we Wrocławiu PL Poland (PL)

How to cite

APA:

Kaminska, J., Dymicka-Piekarska, V., Chrzanowski, R., Sawicki, K., Milewska, A.J., Zinczuk, J.,... Koper-Lenkiewicz, O.M. (2021). IL-6 Quotient (The Ratio of Cerebrospinal Fluid IL-6 to Serum IL-6) as a Biomarker of an Unruptured Intracranial Aneurysm. Journal of Inflammation Research, 14, 6103-6114. https://doi.org/10.2147/JIR.S335618

MLA:

Kaminska, Joanna, et al. "IL-6 Quotient (The Ratio of Cerebrospinal Fluid IL-6 to Serum IL-6) as a Biomarker of an Unruptured Intracranial Aneurysm." Journal of Inflammation Research 14 (2021): 6103-6114.

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