Mesoporous Bioactive Glasses in Cancer Diagnosis and Therapy: Stimuli-Responsive, Toxicity, Immunogenicity, and Clinical Translation
Sharifi E, Bigham A, Yousefiasl S, Trovato M, Ghomi M, Esmaeili Y, Samadi P, Zarrabi A, Ashrafizadeh M, Sharifi S, Sartorius R, Dabbagh Moghaddam F, Maleki A, Song H, Agarwal T, Maiti TK, Nikfarjam N, Burvill C, Mattoli V, Raucci MG, Zheng K, Boccaccini AR, Ambrosio L, Makvandi P (2021)
Publication Type: Journal article, Review article
Publication year: 2021
Journal
Abstract
Cancer is one of the top life-threatening dangers to the human survival, accounting for over 10 million deaths per year. Bioactive glasses have developed dramatically since their discovery 50 years ago, with applications that include therapeutics as well as diagnostics. A new system within the bioactive glass family, mesoporous bioactive glasses (MBGs), has evolved into a multifunctional platform, thanks to MBGs easy-to-functionalize nature and tailorable textural properties—surface area, pore size, and pore volume. Although MBGs have yet to meet their potential in tumor treatment and imaging in practice, recently research has shed light on the distinguished MBGs capabilities as promising theranostic systems for cancer imaging and therapy. This review presents research progress in the field of MBG applications in cancer diagnosis and therapy, including synthesis of MBGs, mechanistic overview of MBGs application in tumor diagnosis and drug monitoring, applications of MBGs in cancer therapy (particularly, targeted delivery and stimuli-responsive nanoplatforms), and immunological profile of MBG-based nanodevices in reference to the development of novel cancer therapeutics.
Authors with CRIS profile
Involved external institutions
Isfahan University of Medical Sciences (IUMS) / دانشگاه علوم پزشکی و خدمات بهداشتی درمانی اصفهان
Iran, Islamic Republic of (IR)
Hamedan University of Medical Sciences
Iran, Islamic Republic of (IR)
Sabanci University
Turkey (TR)
Consiglio Nazionale delle Ricerche (CNR) / National Research Council of Italy
Italy (IT)
Islamic Azad University (IAU) / دانشگاه آزاد اسلامی
Iran, Islamic Republic of (IR)
Zanjan University of Medical Sciences
Iran, Islamic Republic of (IR)
University of Queensland
Australia (AU)
Indian Institute of Technology Kharagpur
India (IN)
Institute for Advanced Studies in Basic Sciences (IASBS) / Zanjan Graduate University of Basic Sciences / انشگاه تحصیلات تکمیلی علوم پایه زنجان
Iran, Islamic Republic of (IR)
Italian Institute of Technology / Istituto Italiano di Tecnologia (IIT)
Italy (IT)
Shahid Chamran University of Ahvaz / دانشگاه شهید چمران اهواز
Iran, Islamic Republic of (IR)
Iran, Islamic Republic of (IR)
Hamedan University of Medical Sciences
Iran, Islamic Republic of (IR)
Sabanci University
Turkey (TR)
Consiglio Nazionale delle Ricerche (CNR) / National Research Council of Italy
Italy (IT)
Islamic Azad University (IAU) / دانشگاه آزاد اسلامی
Iran, Islamic Republic of (IR)
Zanjan University of Medical Sciences
Iran, Islamic Republic of (IR)
University of Queensland
Australia (AU)
Indian Institute of Technology Kharagpur
India (IN)
Institute for Advanced Studies in Basic Sciences (IASBS) / Zanjan Graduate University of Basic Sciences / انشگاه تحصیلات تکمیلی علوم پایه زنجان
Iran, Islamic Republic of (IR)
Italian Institute of Technology / Istituto Italiano di Tecnologia (IIT)
Italy (IT)
Shahid Chamran University of Ahvaz / دانشگاه شهید چمران اهواز
Iran, Islamic Republic of (IR)
How to cite
APA:
Sharifi, E., Bigham, A., Yousefiasl, S., Trovato, M., Ghomi, M., Esmaeili, Y.,... Makvandi, P. (2021). Mesoporous Bioactive Glasses in Cancer Diagnosis and Therapy: Stimuli-Responsive, Toxicity, Immunogenicity, and Clinical Translation. Advanced Science. https://doi.org/10.1002/advs.202102678
MLA:
Sharifi, Esmaeel, et al. "Mesoporous Bioactive Glasses in Cancer Diagnosis and Therapy: Stimuli-Responsive, Toxicity, Immunogenicity, and Clinical Translation." Advanced Science (2021).
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