The microRNA bantam regulates a developmental transition in epithelial cells that restricts sensory dendrite growth
Jiang N, Soba P, Parker E, Kim CC, Parrish JZ (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Book Volume: 141
Pages Range: 2657-2668
Journal Issue: 13
DOI: 10.1242/dev.107573
Abstract
As animals grow, many early born structures grow by cell expansion rather than cell addition; thus growth of distinct structures must be coordinated to maintain proportionality. This phenomenon is particularly widespread in the nervous system, with dendrite arbors of many neurons expanding in concert with their substrate to sustain connectivity and maintain receptive field coverage as animals grow. After rapidly growing to establish body wall coverage, dendrites of Drosophila class IV dendrite arborization (C4da) neurons grow synchronously with their substrate, the body wall epithelium, providing a system to study how proportionality is maintained during animal growth. Here, we show that the microRNA bantam (ban) ensures coordinated growth of C4da dendrites and the epithelium through regulation of epithelial endoreplication, a modified cell cycle that entails genome amplification without cell division. In Drosophila larvae, epithelial endoreplication leads to progressive changes in dendrite-extracellular matrix (ECM) and dendrite-epithelium contacts, coupling dendrite/substrate expansion and restricting dendrite growth beyond established boundaries. Moreover, changes in epithelial expression of cell adhesion molecules, including the beta-integrin myospheroid (mys), accompany this developmental transition. Finally, endoreplication and the accompanying changes in epithelial mys expression are required to constrain late-stage dendrite growth and structural plasticity. Hence, modulating epithelium-ECM attachment probably influences substrate permissivity for dendrite growth and contributes to the dendrite-substrate coupling that ensures proportional expansion of the two cell types. © 2014. Published by The Company of Biologists Ltd.
Authors with CRIS profile
Involved external institutions
University of Washington
United States (USA) (US)
University of California San Francisco (UCSF)
United States (USA) (US)
Universitätsklinikum Hamburg-Eppendorf (UKE)
Germany (DE)
United States (USA) (US)
University of California San Francisco (UCSF)
United States (USA) (US)
Universitätsklinikum Hamburg-Eppendorf (UKE)
Germany (DE)
How to cite
APA:
Jiang, N., Soba, P., Parker, E., Kim, C.C., & Parrish, J.Z. (2014). The microRNA bantam regulates a developmental transition in epithelial cells that restricts sensory dendrite growth. Development, 141(13), 2657-2668. https://doi.org/10.1242/dev.107573
MLA:
Jiang, Nan, et al. "The microRNA bantam regulates a developmental transition in epithelial cells that restricts sensory dendrite growth." Development 141.13 (2014): 2657-2668.
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