A Predictive Model for Progression of CKD to Kidney Failure Based on Routine Laboratory Tests

Zacharias HU, Altenbuchinger M, Schultheiss UT, Raffler J, Kotsis F, Ghasemi S, Ali I, Kollerits B, Metzger M, Steinbrenner I, Sekula P, Massy ZA, Combe C, Kalra PA, Kronenberg F, Stengel B, Eckardt KU, Köttgen A, Schmid M, Gronwald W, Oefner PJ (2021)

Publication Type: Journal article

Publication year: 2021


DOI: 10.1053/j.ajkd.2021.05.018


Rationale & Objective: Stratification of chronic kidney disease (CKD) patients at risk for progressing to kidney failure requiring kidney replacement therapy (KFRT) is important for clinical decision-making and trial enrollment. Study Design: Four independent prospective observational cohort studies. Setting & Participants: The development cohort comprised 4,915 CKD patients, and 3 independent validation cohorts comprised a total of 3,063. Patients were observed for approximately 5 years. Exposure: 22 demographic, anthropometric, and laboratory variables commonly assessed in CKD patients. Outcome: Progression to KFRT. Analytical Approach: A least absolute shrinkage and selection operator (LASSO) Cox proportional hazards model was fit to select laboratory variables that best identified patients at high risk for KFRT. Model discrimination and calibration were assessed and compared against the 4-variable Tangri (T4) risk equation both in a resampling approach within the development cohort and in the validation cohorts using cause-specific concordance (C) statistics, net reclassification improvement, and calibration graphs. Results: The newly derived 6-variable risk score (Z6) included serum creatinine, albumin, cystatin C, and urea, as well as hemoglobin and the urinary albumin-creatinine ratio. In the the resampling approach, Z6 achieved a median C statistic of 0.909 (95% CI, 0.868-0.937) at 2 years after the baseline visit, whereas the T4 achieved a median C statistic of 0.855 (95% CI, 0.799-0.915). In the 3 independent validation cohorts, the Z6 C statistics were 0.894, 0.921, and 0.891, whereas the T4 C statistics were 0.882, 0.913, and 0.862. Limitations: The Z6 was both derived and tested only in White European cohorts. Conclusions: A new risk equation based on 6 routinely available laboratory tests facilitates identification of patients with CKD who are at high risk of progressing to KFRT.

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Zacharias, H.U., Altenbuchinger, M., Schultheiss, U.T., Raffler, J., Kotsis, F., Ghasemi, S.,... Oefner, P.J. (2021). A Predictive Model for Progression of CKD to Kidney Failure Based on Routine Laboratory Tests. American Journal of Kidney Diseases. https://doi.org/10.1053/j.ajkd.2021.05.018


Zacharias, Helena U., et al. "A Predictive Model for Progression of CKD to Kidney Failure Based on Routine Laboratory Tests." American Journal of Kidney Diseases (2021).

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