Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes

Sahoo SS, Pastor VB, Goodings C, Voss RK, Kozyra EJ, Szvetnik A, Noellke P, Dworzak M, Stary J, Locatelli F, Masetti R, Schmugge M, De Moerloose B, Catala A, Kallay K, Turkiewicz D, Hasle H, Buechner J, Jahnukainen K, Ussowicz M, Polychronopoulou S, Smith OP, Fabri O, Barzilai S, De Haas V, Baumann I, Schwarz-Furlan S, Niewisch MR, Sauer MG, Burkhardt B, Lang P, Bader P, Beier R, Mueller I, Albert MH, Meisel R, Schulz A, Cario G, Panda PK, Wehrle J, Hirabayashi S, Derecka M, Durruthy-Durruthy R, Goehring G, Yoshimi-Noellke A, Ku M, Lebrecht D, Erlacher M, Flotho C, Strahm B, Niemeyer CM, Wlodarski MW (2021)

Publication Type: Journal article

Publication year: 2021

Journal

DOI: 10.1038/s41591-021-01511-6

Abstract

This analysis of a large, clinically annotated cohort of individuals with predisposition to myelodysplastic syndromes reveals insights into the genetic determinants of disease progression and their relationship with clinical manifestations and therapy outcome.

Authors with CRIS profile

Involved external institutions

Institut für Pathologie Kaufbeuren-Ravensburg GbR Germany (DE) St. Jude Children’s Research Hospital United States (USA) (US) Albert-Ludwigs-Universität Freiburg Germany (DE) Medizinische Universität Wien Austria (AT) Univerzita Karlova v Praze / Charles University in Prague Czech Republic (CZ) Università degli studi "La Sapienza" Italy (IT) Ospedaliero Universitaria di Bologna Policlinico S.Orsola-Malpighi Italy (IT) Universitäts-Kinderspital Zürich Switzerland (CH) Universiteit Gent (UGent) / Ghent University Belgium (BE) Hospital Sant Joan de Déu Barcelona Spain (ES) Skåne University Hospital / Skånes universitetssjukhus Sweden (SE) Aarhus University Hospital / Aarhus Universitetshospital Denmark (DK) Oslo University Hospital / Oslo Universitetssykehus Rikshospitalet Norway (NO) Helsingin yliopisto / University of Helsinki Finland (FI) Wrocław Medical University / Uniwersytet Medyczny we Wrocławiu Poland (PL) "Aghia Sofia" General Children's Hospital Greece (GR) Temple Street Children's University Hospital / Children's Health Ireland (CHI) Ireland (IE) Comenius University Bratislava Slovakia (SK) Tel Aviv University Israel (IL) Dutch Childhood Oncology Group Netherlands (NL) Medizinische Hochschule Hannover (MHH) / Hannover Medical School Germany (DE) Universitätsklinikum Münster Germany (DE) Eberhard Karls Universität Tübingen Germany (DE) Universitätsklinikum Frankfurt am Main (KGU) Germany (DE) Universitätsklinikum Essen Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Ludwig-Maximilians-Universität (LMU) Germany (DE) Heinrich-Heine-Universität Düsseldorf Germany (DE) Universitätsklinikum Ulm Germany (DE) Universitätsklinikum Schleswig-Holstein (UKSH) Germany (DE) Mission Bio Ltd. United States (USA) (US)

How to cite

APA:

Sahoo, S.S., Pastor, V.B., Goodings, C., Voss, R.K., Kozyra, E.J., Szvetnik, A.,... Wlodarski, M.W. (2021). Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes. Nature Medicine. https://doi.org/10.1038/s41591-021-01511-6

MLA:

Sahoo, Sushree S., et al. "Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes." Nature Medicine (2021).

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