Dynamic, transient, and robust increase in the innervation of the inflamed mucosa in inflammatory bowel diseases

Gonzalez Acera M, Bubeck M, Mascia F, Diemand L, Sturm G, Kuehl AA, Atreya R, Lie DC, Neurath M, Schumann M, Klose CSN, Trajanoski Z, Becker C, Patankar J (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Cells MDPI

Book Volume: 10

Article Number: 2253

Journal Issue: 9

DOI: 10.3390/cells10092253

Abstract

Inflammatory bowel diseases (IBD) are characterized by chronic dysregulation of immune homeostasis, epithelial demise, immune cell activation, and microbial translocation. Each of these processes leads to proinflammatory changes via the release of cytokines, damage-associated molecular patterns (DAMPs), and pathogen-associated molecular patterns (PAMPs), respectively. The impact of these noxious agents on the survival and function of the enteric nervous system (ENS) is poorly understood. Here, we show that in contrast to an expected decrease, experimental as well as clinical colitis causes an increase in the transcript levels of enteric neuronal and glial genes. Immunostaining revealed an elevated neuronal innervation of the inflamed regions of the gut mucosa. The increase was seen in models with overt damage to epithelial cells and models of T cell-induced colitis. Transcriptomic data from treatment naïve pediatric IBD patients also confirmed the increase in the neuroglial genes and were replicated on an independent adult IBD dataset. This induction in the neuroglial genes was transient as levels returned to normal upon the induction of remission in both mouse models as well as colitis patients. Our data highlight the dynamic and robust nature of the enteric nervous system in colitis and open novel questions on its regulation.

Authors with CRIS profile

Miguel Gonzalez Acera Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Marvin Bubeck Lehrstuhl für Genetik Fabrizio Mascia Lehrstuhl für Biochemie und Molekulare Medizin Raja Atreya Professur für Translationale Immunforschung bei chronisch entzündlichen Darmerkrankungen Dieter Chichung Lie Institut für Biochemie Markus Neurath Lehrstuhl für Innere Medizin I (Medizin 1) Christoph Becker Professur für Molekulare Gastroenterologie Jay Patankar Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology

Involved external institutions

Charité - Universitätsmedizin Berlin DE Germany (DE) Medizinische Universität Innsbruck AT Austria (AT) Freie Universität Berlin DE Germany (DE)

How to cite

APA:

Gonzalez Acera, M., Bubeck, M., Mascia, F., Diemand, L., Sturm, G., Kuehl, A.A.,... Patankar, J. (2021). Dynamic, transient, and robust increase in the innervation of the inflamed mucosa in inflammatory bowel diseases. Cells, 10(9). https://doi.org/10.3390/cells10092253

MLA:

Gonzalez Acera, Miguel, et al. "Dynamic, transient, and robust increase in the innervation of the inflamed mucosa in inflammatory bowel diseases." Cells 10.9 (2021).

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