Reaction mechanisms relevant to the formation and utilization of [Ru(edta)(NO)] complexes in aqueous media

Chatterjee D, Chrzanowska M, Katafias A, van Eldik R (2021)

Publication Type: Journal article, Review article

Publication year: 2021

Journal

Journal of Inorganic Biochemistry Elsevier

Book Volume: 225

Article Number: 111595

DOI: 10.1016/j.jinorgbio.2021.111595

Abstract

The advancement of Ru(edta) complexes (edta4− = ethylenediamineteraacetate) mediated reactions, including NO generation and its utilization, has not been systematically reviewed to date. This review aims to report the research progress that has been made in exploring the application of Ru(edta) complexes in trapping and generation of NO. Furthermore, utilization of the potential of Ru(edta) complexes to mimic NO synthase and nitrite reductase activity, including thermodynamics and kinetics of NO binding to Ru(edta) complexes, their NO scavenging (in vitro), and antitumor activity will be discussed. Also, the role of [Ru(edta)(NO)] in mediating electrochemical reduction of nitrite, S-nitrosylation of biological thiols, and cross-talk between NO and H2S, will be covered. Reports on the NO-related chemistry of Fe(edta) complexes showing similar behavior are contextualized in this review for comparison purposes. The research contributions compiled herein will provide in-depth mechanistic knowledge for understanding the diverse routes pertaining to the formation of the [Ru(edta)(NO)] species, and its role in effecting the aforementioned reactions of biochemical significance.

Authors with CRIS profile

Rudi van Eldik Naturwissenschaftliche Fakultät

Involved external institutions

Nicolaus Copernicus University (NCU) / Uniwersytet Mikołaja Kopernika w Toruniu (UMK) PL Poland (PL) The University of Burdwan IN India (IN)

How to cite

APA:

Chatterjee, D., Chrzanowska, M., Katafias, A., & van Eldik, R. (2021). Reaction mechanisms relevant to the formation and utilization of [Ru(edta)(NO)] complexes in aqueous media. Journal of Inorganic Biochemistry, 225. https://doi.org/10.1016/j.jinorgbio.2021.111595

MLA:

Chatterjee, Debabrata, et al. "Reaction mechanisms relevant to the formation and utilization of [Ru(edta)(NO)] complexes in aqueous media." Journal of Inorganic Biochemistry 225 (2021).

BibTeX: Download