Effects of Vimentin Intermediate Filaments on the Structure and Dynamics of in Vitro Multicomponent Interpenetrating Cytoskeletal Networks
Shen Y, Wu H, Lu PJ, Wang D, Shayegan M, Li H, Shi W, Wang Z, Cai LH, Xia J, Zhang M, Ding R, Herrmann H, Goldman R, Mackintosh FC, Moncho-Jorda A, Weitz DA (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 127
Article Number: 108101
Journal Issue: 10
DOI: 10.1103/PhysRevLett.127.108101
Abstract
We investigate the rheological properties of interpenetrating networks reconstituted from the main cytoskeletal components: filamentous actin, microtubules, and vimentin intermediate filaments. The elastic modulus is determined largely by actin, with little contribution from either microtubules or vimentin. However, vimentin dramatically impacts the relaxation, with even small amounts significantly increasing the relaxation time of the interpenetrating network. This highly unusual decoupling between dissipation and elasticity may reflect weak attractive interactions between vimentin and actin networks.
Additional Organisation(s)
Involved external institutions
Harvard University
United States (USA) (US)
Beijing Normal University
China (CN)
Rice University
United States (USA) (US)
Nankai University (NKU) / 南开大学
China (CN)
Deutsches Krebsforschungszentrum (DKFZ)
Germany (DE)
Northwestern University
United States (USA) (US)
Universidad de Granada
Spain (ES)
University of Virginia (UVA)
United States (USA) (US)
United States (USA) (US)
Beijing Normal University
China (CN)
Rice University
United States (USA) (US)
Nankai University (NKU) / 南开大学
China (CN)
Deutsches Krebsforschungszentrum (DKFZ)
Germany (DE)
Northwestern University
United States (USA) (US)
Universidad de Granada
Spain (ES)
University of Virginia (UVA)
United States (USA) (US)
How to cite
APA:
Shen, Y., Wu, H., Lu, P.J., Wang, D., Shayegan, M., Li, H.,... Weitz, D.A. (2021). Effects of Vimentin Intermediate Filaments on the Structure and Dynamics of in Vitro Multicomponent Interpenetrating Cytoskeletal Networks. Physical Review Letters, 127(10). https://doi.org/10.1103/PhysRevLett.127.108101
MLA:
Shen, Yinan, et al. "Effects of Vimentin Intermediate Filaments on the Structure and Dynamics of in Vitro Multicomponent Interpenetrating Cytoskeletal Networks." Physical Review Letters 127.10 (2021).
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