Echo time dependence of biexponential and triexponential intravoxel incoherent motion parameters in the liver

Führes T, Riexinger A, Loh M, Martin J, Wetscherek A, Kuder TA, Uder M, Hensel B, Laun FB (2021)

Publication Language: English

Publication Type: Journal article

Publication year: 2021

Journal

Magnetic Resonance in Medicine Wiley

DOI: 10.1002/mrm.28996

Abstract

Purpose Intravoxel incoherent motion (IVIM) studies are performed with different acquisition protocols. Comparing them requires knowledge of echo time (TE) dependencies. The TE-dependence of the biexponential perfusion fraction f is well-documented, unlike that of its triexponential counterparts f(1) and f(2) and the biexponential and triexponential pseudodiffusion coefficients D*, D1*, and D2*. The purpose was to investigate the TE-dependence of these parameters and to check whether the triexponential pseudodiffusion compartments are associated with arterial and venous blood. Methods Fifteen healthy volunteers (19-58 y; mean: 24.7 y) underwent diffusion-weighted imaging of the abdomen with 24 b-values (0.2-800 s/mm(2)) at TEs of 45, 60, 75, and 90 ms. Regions of interest (ROIs) were manually drawn in the liver. One set of bi- and triexponential IVIM parameters per volunteer and TE was determined. The TE-dependence was assessed with the Kruskal-Wallis test. Results TE-dependence was observed for f (P < .001), f(1) (P = .001), and f(2) (P < .001). Their median values at the four measured TEs were: f: 0.198/0.240/0.274/0.359, f(1): 0.113/0.139/0.146/0.205, f(2): 0.115/0.155/0.182/0.194. D, D*, D1*, and D2* showed no significant TE-dependence. Their values were: diffusion coefficient D (10(-4) mm(2)/s): 9.45/9.63/9.75/9.41, biexponential D* (10(-2) mm(2)/s): 5.26/5.52/6.13/5.82, triexponential D1* (10(-2) mm(2)/s): 1.73/2.91/2.25/2.51, triexponential D2* (mm(2)/s): 0.478/1.385/0.616/0.846. Conclusion f(1) and f(2) show similar TE-dependence as f, ie, increase with rising TE; an effect that must be accounted for when comparing different studies. The diffusion and pseudodiffusion coefficients might be compared without TE correction. Because of the similar TE-dependence of f(1) and f(2), the triexponential pseudodiffusion compartments are most probably not associated to venous and arterial blood.

Authors with CRIS profile

Tobit Führes Professur für quantitative MR-Bildgebung (Heisenberg-Professur) Andreas Riexinger Institute of Radiology Martin Loh Lehrstuhl für Informatik 5 (Mustererkennung) Michael Uder Lehrstuhl für Diagnostische Radiologie Bernhard Hensel Max Schaldach-Stiftungsprofessur für Biomedizinische Technik Frederik Bernd Laun Professur für quantitative MR-Bildgebung (Heisenberg-Professur)

Involved external institutions

Deutsches Krebsforschungszentrum (DKFZ) DE Germany (DE) The Institute of Cancer Research (ICR) GB United Kingdom (GB) Lund University / Lunds universitet SE Sweden (SE)

How to cite

APA:

Führes, T., Riexinger, A., Loh, M., Martin, J., Wetscherek, A., Kuder, T.A.,... Laun, F.B. (2021). Echo time dependence of biexponential and triexponential intravoxel incoherent motion parameters in the liver. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.28996

MLA:

Führes, Tobit, et al. "Echo time dependence of biexponential and triexponential intravoxel incoherent motion parameters in the liver." Magnetic Resonance in Medicine (2021).

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