Effect of Heart Rate on the Outcome of Renal Denervation in Patients With Uncontrolled Hypertension

Böhm M, Tsioufis K, Kandzari DE, Kario K, Weber MA, Schmieder R, Townsend RR, Kulenthiran S, Ukena C, Pocock S, Ewen S, Weil J, Fahy M, Mahfoud F (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Journal of the American College of Cardiology Elsevier

Book Volume: 78

Pages Range: 1028-1038

Journal Issue: 10

DOI: 10.1016/j.jacc.2021.06.044

Abstract

Background: Sham-controlled trials demonstrated safety and efficacy of renal denervation (RDN) to lower blood pressure (BP). Association of baseline heart rate with BP reduction after RDN is incompletely understood. Objectives: The purpose of this analysis was to evaluate the impact of baseline heart rate on BP reduction without antihypertensive medications in the SPYRAL HTN-OFF MED (Global Clinical Study of Renal Denervation With the Symplicity Spyral Multi-electrode Renal Denervation System in Patients With Uncontrolled Hypertension in the Absence of Antihypertensive Medications) Pivotal trial. Methods: Patients removed from any antihypertensive medications were enrolled with office systolic blood pressure (SBP) ≥150 and <180 mm Hg and randomized 1:1 to RDN or sham control. Patients were separated according to baseline office heart rate <70 or ≥70 beats/min. BP changes from baseline to 3 months between treatment arms were adjusted for baseline SBP using analysis of covariance. Results: Scatter plots of 3-month changes in 24-hour and office SBP illustrate a wide range of changes in SBP for different baseline heart rates. Treatment difference at 3 months between RDN and sham control with baseline office heart rate ≥70 beats/min for 24-hour SBP was −6.2 mm Hg (95% CI: −9.0 to −3.5 mm Hg) (P < 0.001) and for baseline office heart rate <70 beats/min it was −0.1 mm Hg (−3.8 to 3.6 mm Hg) (P = 0.97) with an interaction P value of 0.008. Results were similar for changes in office, daytime, and nighttime SBP at 3 months, with a greater reduction in SBP with baseline office heart rate ≥70 beats/min. Conclusions: Reduction in mean office, 24-hour, daytime, and nighttime SBP for RDN at 3 months was greater with baseline office heart rate ≥70 than <70 beats/min, suggesting an association between baseline heart rate and BP reduction after RDN. (SPYRAL PIVOTAL—SPYRAL HTN-OFF MED Study; NCT02439749)

Authors with CRIS profile

Roland Schmieder Professur für Innere Medizin (Nephrologie)

Involved external institutions

Universitätsklinikum des Saarlandes (UKS) DE Germany (DE) Piedmont Healthcare US United States (USA) (US) Perelman School of Medicine University of Pennsylvania US United States (USA) (US) Jichi Medical University / 自治医科大学 JP Japan (JP) National and Kapodistrian University of Athens GR Greece (GR) SUNY Downstate Medical Center US United States (USA) (US) Sana Kliniken AG DE Germany (DE) London School of Hygiene and Tropical Medicine GB United Kingdom (GB) Medtronic US United States (USA) (US)

How to cite

APA:

Böhm, M., Tsioufis, K., Kandzari, D.E., Kario, K., Weber, M.A., Schmieder, R.,... Mahfoud, F. (2021). Effect of Heart Rate on the Outcome of Renal Denervation in Patients With Uncontrolled Hypertension. Journal of the American College of Cardiology, 78(10), 1028-1038. https://dx.doi.org/10.1016/j.jacc.2021.06.044

MLA:

Böhm, Michael, et al. "Effect of Heart Rate on the Outcome of Renal Denervation in Patients With Uncontrolled Hypertension." Journal of the American College of Cardiology 78.10 (2021): 1028-1038.

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