The role of the immune system in malignant and inflammatory diseases in oral and maxillofacial surgery

Weber M, Ries J, Wehrhan F, Kesting MR (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Der MKG-Chirurg Springer Verlag

DOI: 10.1007/s12285-021-00322-5

Abstract

The introduction of pharmacological immunotherapy has revolutionized the treatment of tumor diseases in many medical specialties. Nevertheless, the understanding of the regulation of the immune system and the relationship between the immune system, inflammation and malignancy is incomplete. The goal of this work was to better understand the role of the immune system in malignant and inflammatory diseases in oral and maxillofacial surgery to lay the foundation for future therapies. The balance between immunity and immune tolerance is disturbed in inflammation and in malignancies. In inflammation, there is a shift towards increased destructive immunity while in malignancy immune tolerance is pathologically increased, allowing the tumor to evade the body's defense response. Surgical procedures also influence the immune system response. The treatment of inflammatory and malignant diseases can potentially be improved if surgical treatment and pharmacological immunotherapy are skillfully combined.

Authors with CRIS profile

Manuel Weber Department of Oral and Cranio-Maxillofacial Surgery Jutta Ries Medizinische Fakultät Falk Wehrhan Department of Oral and Cranio-Maxillofacial Surgery Marco Rainer Kesting Lehrstuhl für Zahnmedizin, insbesondere Mund-, Kiefer-, und Gesichtschirurgie

How to cite

APA:

Weber, M., Ries, J., Wehrhan, F., & Kesting, M.R. (2021). The role of the immune system in malignant and inflammatory diseases in oral and maxillofacial surgery. Der MKG-Chirurg. https://dx.doi.org/10.1007/s12285-021-00322-5

MLA:

Weber, Manuel, et al. "The role of the immune system in malignant and inflammatory diseases in oral and maxillofacial surgery." Der MKG-Chirurg (2021).

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