microRNAs in the pathogenesis of non-obstructive azoospermia: the underlying mechanisms and therapeutic potentials
Rezaei YR, Zarezadeh R, Nikanfar S, Oghbaei H, Nazdikbin N, Bahrami-Asl Z, Zarghami N, Ahmadi Y, Fattahi A, Nouri M, Dittrich R (2021)
Publication Type: Journal article, Review article
Publication year: 2021
Journal
DOI: 10.1080/19396368.2021.1951890
Abstract
miRNAs are involved in different biological processes, including proliferation, differentiation, and apoptosis. Interestingly, 38% of the X chromosome-linked miRNAs are testis-specific and have crucial roles in regulating the renewal and cell cycle of spermatogonial stem cells. Previous studies demonstrated that abnormal expression of spermatogenesis-related miRNAs could lead to nonobstructive azoospermia (NOA). Moreover, differential miRNAs expression in seminal plasma of NOA patients has been reported compared to normozoospermic men. However, the role of miRNAs in NOA pathogenesis and the underlying mechanisms have not been comprehensively studied. Therefore, the aim of this review is to mechanistically describe the role of miRNAs in the pathogenesis of NOA and discuss the possibility of using the miRNAs as therapeutic targets.
Authors with CRIS profile
Involved external institutions
Tabriz University of Medical Sciences (TBZMED) / دانشگاه علوم پزشکی تبریز
Iran, Islamic Republic of (IR)
Islamic Azad University (IAU) / دانشگاه آزاد اسلامی
Iran, Islamic Republic of (IR)
Iran, Islamic Republic of (IR)
Islamic Azad University (IAU) / دانشگاه آزاد اسلامی
Iran, Islamic Republic of (IR)
How to cite
APA:
Rezaei, Y.R., Zarezadeh, R., Nikanfar, S., Oghbaei, H., Nazdikbin, N., Bahrami-Asl, Z.,... Dittrich, R. (2021). microRNAs in the pathogenesis of non-obstructive azoospermia: the underlying mechanisms and therapeutic potentials. Systems Biology in Reproductive Medicine. https://dx.doi.org/10.1080/19396368.2021.1951890
MLA:
Rezaei, Yeganeh Rastgar, et al. "microRNAs in the pathogenesis of non-obstructive azoospermia: the underlying mechanisms and therapeutic potentials." Systems Biology in Reproductive Medicine (2021).
BibTeX: Download