Expression of surface-associated 82 kda prommp-9 in lymphatic leukemia blast cells differentially correlates with prognosis
Schmohl J, Möbius S, Günther T, Pepeldjyika E, Seidel CL, Sutanto W, Schuster F, Kraemer D, Salih HR, Hartmann A, Tischer J, Ries C, Schmetzer H (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 41
Pages Range: 3891-3898
Journal Issue: 8
DOI: 10.21873/anticanres.15184
Abstract
Background/Aim: Matrix metalloproteinases (MMPs) degrade extracellular matrix and process regulatory proteins. Recently, a membrane-bound 82kDa variant of proMMP-9 identified on myeloid blasts was shown to be associated with prognosis. Patients and Methods: To investigate the role of 82kDa proMMP-9 with acute lymphoblastic leukemia (ALL) and chronic lymphoid leukemia (CLL), we performed flow-cytometry analysis of expression on ALL blasts (n=18) and CLL lymphocytes (n=21) from blood and correlated data with clinical parameters. Results: In ALL, mature B-linear blasts expressed higher levels of 82kDa proMMP-9 compared to T-linear blasts. Elevated levels of 82kDa proMMP-9 were found in elderly patients and at patients with relapse. No correlation was observed on blood cells and extramedullary disease. In CLL, the 82kDa proMMP-9 expression did not correlate with any of the clinical parameters. Conclusion: Our findings suggest that higher levels of 82kDa proMMP-9 expression on blast cells may correlate with a more unfavorable ALL-subtype. Further studies are required to clarify the prognostic role of the 82kDa pro-MMP-9 expression.
Involved external institutions
Klinikum der Universität München
Germany (DE)
Eberhard Karls Universität Tübingen
Germany (DE)
St Josefs-Hospital
Germany (DE)
Diakonie-Klinikum Stuttgart Diakonissenkrankenhaus und Paulinenhilfe
Germany (DE)
Universitätsklinikum Düsseldorf
Germany (DE)
Germany (DE)
Eberhard Karls Universität Tübingen
Germany (DE)
St Josefs-Hospital
Germany (DE)
Diakonie-Klinikum Stuttgart Diakonissenkrankenhaus und Paulinenhilfe
Germany (DE)
Universitätsklinikum Düsseldorf
Germany (DE)
How to cite
APA:
Schmohl, J., Möbius, S., Günther, T., Pepeldjyika, E., Seidel, C.L., Sutanto, W.,... Schmetzer, H. (2021). Expression of surface-associated 82 kda prommp-9 in lymphatic leukemia blast cells differentially correlates with prognosis. Anticancer Research, 41(8), 3891-3898. https://doi.org/10.21873/anticanres.15184
MLA:
Schmohl, Jörg, et al. "Expression of surface-associated 82 kda prommp-9 in lymphatic leukemia blast cells differentially correlates with prognosis." Anticancer Research 41.8 (2021): 3891-3898.
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