A placental specific miRNA miR-517a-3p exerts anti-human cytomegalovirus activity

Hamilton ST, Hahn F, Sonntag E, Marschall M, Rawlinson WD (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Placenta Elsevier

Book Volume: 112

Pages Range: 62-65

DOI: 10.1016/j.placenta.2021.06.013

Abstract

Human cytomegalovirus congenital infection is the leading non-genetic cause of fetal malformation in developed countries. There are currently no safe antivirals for use during pregnancy. Placental trophoblast cells specifically secrete exosomes containing miRNA from the chromosome 19 miRNA cluster (C19MC) which confer viral resistance to recipient cells. We show the highly expressed C19MC miRNA miR-517a-3p inhibits HCMV replication and viral protein expression in both fibroblast and trophoblast cell cultures (71.6% and 50.4% inhibition of HCMV DNA at 7 days post infection respectively; p < 0.05). This naturally occurring molecule has potential for opening-up antiviral therapeutic strategies for pregnancy.

Authors with CRIS profile

Friedrich Hahn Institute of Clinical and Molecular Virology Manfred Marschall Lehrstuhl für Klinische und Molekulare Virologie

Additional Organisation(s)

Interdisziplinäres Zentrum für Klinische Forschung

Related research project(s)

None - None A088: Regulatory interaction btw. cyclins and cytomegalovirus kinase pUL97: focus on pUL97 drug resistance mutations Feb. 1, 2020 - July 31, 2023

Involved external institutions

Prince of Wales Hospital (POWH) AU Australia (AU)

How to cite

APA:

Hamilton, S.T., Hahn, F., Sonntag, E., Marschall, M., & Rawlinson, W.D. (2021). A placental specific miRNA miR-517a-3p exerts anti-human cytomegalovirus activity. Placenta, 112, 62-65. https://doi.org/10.1016/j.placenta.2021.06.013

MLA:

Hamilton, Stuart T., et al. "A placental specific miRNA miR-517a-3p exerts anti-human cytomegalovirus activity." Placenta 112 (2021): 62-65.

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