Löhberg C, Heusinger K, Jud S, Häberle L, Hein A, Rauh C, Bani M, Lux MP, Schrauder MG, Bayer CM, Helbig C, Grolik R, Adamietz B, Schulz-Wendtland R, Beckmann M, Fasching P (2010)
Publication Type: Journal article
Publication year: 2010
Book Volume: 19
Pages Range: 405-412
Journal Issue: 6
DOI: 10.1097/CEJ.0b013e32833ca1f4
Mammographic density (MD) has consistently been found as one of the strongest breast cancer risk factors. In our study, both qualitative and quantitative density measurements were performed in a hospital-based group of premenopausal women before and after first full-term pregnancy providing an opportunity for direct evaluation of the effects of one pregnancy on MD. Mammograms were obtained from 23 women before and after first full-term pregnancy and from 28 nulliparous controls. MD was determined by a standard qualitative assessment method using the Breast Imaging Reporting and Data System, and a quantitative computer-based threshold method (0-100%). The mean age at mammography before and after pregnancy was 31 and 34 years, respectively, with a mean difference of 40 months between mammographies. The quantitative density assessment showed a significant reduction in relative MD after pregnancy of 12 percentage points (8.6-15.4), compared with 3.1 (0.0-6.2) in the nulliparous control group (P<0.001). A reduction in MD of more than 10% was seen in 52% of the patients, compared with 18% of the controls. The qualitative density assessment confirmed a reduction in MD after pregnancy by one Breast Imaging Reporting and Data System category (P=0.02). This longitudinal study showed that MD can be influenced by one full-term pregnancy. This effect was seen with both quantitative and qualitative assessment methods. It may be hypothesized that breast cancer risk reduction associated with pregnancy is mediated through a direct reduction of MD, and MD assessment might be incorporated in individualizing risk assessment and prevention. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
APA:
Löhberg, C., Heusinger, K., Jud, S., Häberle, L., Hein, A., Rauh, C.,... Fasching, P. (2010). Assessment of mammographic density before and after first full-term pregnancy. European Journal of Cancer Prevention, 19(6), 405-412. https://doi.org/10.1097/CEJ.0b013e32833ca1f4
MLA:
Löhberg, Christian, et al. "Assessment of mammographic density before and after first full-term pregnancy." European Journal of Cancer Prevention 19.6 (2010): 405-412.
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