Genome-wide association study identifies a common variant associated with risk of endometrial cancer

Spurdle AB, Thompson DJ, Ahmed S, Ferguson K, Healey CS, O'Mara T, Walker LC, Montgomery SB, Dermitzakis ET, Fahey P, Montgomery GW, Webb PM, Fasching PA, Beckmann M, Ekici AB, Hein A, Lambrechts D, Coenegrachts L, Vergote I, Amant F, Salvesen HB, Trovik J, Njolstad TS, Helland H, Scott RJ, Ashton K, Proietto T, Otton G, Tomlinson I, Gorman M, Howarth K, Hodgson S, Garcia-Closas M, Wentzensen N, Yang H, Chanock S, Hall P, Czene K, Liu J, Li J, Shu XO, Zheng W, Long J, Xiang YB, Shah M, Morrison J, Michailidou K, Pharoah PD, Dunning AM, Easton DF (2011)

Publication Type: Journal article

Publication year: 2011

Journal

Book Volume: 43

Pages Range: 451-455

Journal Issue: 5

DOI: 10.1038/ng.812

Abstract

Endometrial cancer is the most common malignancy of the female genital tract in developed countries. To identify genetic variants associated with endometrial cancer risk, we performed a genome-wide association study involving 1,265 individuals with endometrial cancer (cases) from Australia and the UK and 5,190 controls from the Wellcome Trust Case Control Consortium. We compared genotype frequencies in cases and controls for 519,655 SNPs. Forty seven SNPs that showed evidence of association with endometrial cancer in stage 1 were genotyped in 3,957 additional cases and 6,886 controls. We identified an endometrial cancer susceptibility locus close to HNF1B at 17q12 (rs4430796, P = 7.1 × 10^-10) that is also associated with risk of prostate cancer and is inversely associated with risk of type 2 diabetes. © 2011 Nature America, Inc. All rights reserved.

Authors with CRIS profile

Involved external institutions

Haukeland University Hospital / Haukeland universitetssykehus Norway (NO) University of California Los Angeles (UCLA) United States (USA) (US) University of Cambridge United Kingdom (GB) University of Newcastle (UoN) Australia (AU) Karolinska Institute Sweden (SE) Genome Institute of Singapore Singapore (SG) QIMR Berghofer Medical Research Institute (früher: the Queensland Institute of Medical Research) Australia (AU) Vanderbilt University United States (USA) (US) National Cancer Institute (NCI) United States (USA) (US) University of Geneva / Université de Genève (UNIGE) Switzerland (CH) University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven Belgium (BE) University of Oxford United Kingdom (GB) St George's, University of London (SGUL) / St George's Hospital Medical School United Kingdom (GB) Shanghai Cancer Institute / 上海市肿瘤研究所 China (CN) Flanders Institute for Biotechnology / Vlaams Instituut voor Biotechnologie (VIB) Belgium (BE)

How to cite

APA:

Spurdle, A.B., Thompson, D.J., Ahmed, S., Ferguson, K., Healey, C.S., O'Mara, T.,... Easton, D.F. (2011). Genome-wide association study identifies a common variant associated with risk of endometrial cancer. Nature Genetics, 43(5), 451-455. https://doi.org/10.1038/ng.812

MLA:

Spurdle, Amanda B., et al. "Genome-wide association study identifies a common variant associated with risk of endometrial cancer." Nature Genetics 43.5 (2011): 451-455.

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