Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk: Pooled analysis within the ovarian cancer association consortium

Lurie G, Wilkens LR, Thompson PJ, Shvetsov YB, Matsuno RK, Carney ME, Palmieri RT, Wu AH, Pike MC, Pearce CL, Menon U, Gentry-Maharaj A, Gayther SA, Ramus SJ, Whittemore AS, Mcguire V, Sieh W, Pharoah PDP, Song H, Gronwald J, Jakubowska A, Cybulski C, Lubinski J, Schildkraut JM, Berchuck A, Kjaer SK, Hogdall E, Fasching PA, Beckmann M, Ekici AB, Hein A, Chenevix-Trench G, Webb PM, Beesley J, Goodman MT (2011)

Publication Type: Journal article

Publication year: 2011

Journal

Book Volume: 6

Article Number: e20703

Journal Issue: 6

DOI: 10.1371/journal.pone.0020703

Abstract

The association of ovarian carcinoma risk with the polymorphism rs1271572 in the estrogen receptor beta (ESR2) gene was examined in 4946 women with primary invasive ovarian carcinoma and 6582 controls in a pooled analysis of ten case-control studies within the Ovarian Cancer Association Consortium (OCAC). All participants were non-Hispanic white women. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression adjusted for site and age. Women with the TT genotype were at increased risk of ovarian carcinoma compared to carriers of the G allele (OR = 1.10; 95%; CI: 1.01-1.21; p = 0.04); the OR was 1.09 (CI: 0.99-1.20; p = 0.07) after excluding data from the center (Hawaii) that nominated this SNP for OCAC genotyping A stronger association of rs1271572 TT versus GT/GG with risk was observed among women aged ≤50 years versus older women (OR = 1.35; CI: 1.12-1.62; p = 0.002; p for interaction = 0.02) that remained statistically significant after excluding Hawaii data (OR = 1.34; CI: 1.11-1.61; p = 0.009). No heterogeneity of the association was observed by study, menopausal status, gravidity, parity, use of contraceptive or menopausal hormones, tumor histological type, or stage at diagnosis. This pooled analysis suggests that rs1271572 might influence the risk of ovarian cancer, in particular among younger women. © 2011 Lurie et al.

Authors with CRIS profile

Involved external institutions

Stanford University United States (USA) (US) Pomeranian Medical University / Pomorski Uniwersytet Medyczny w Szczecinie (PMU) Poland (PL) University of Southern California (USC) United States (USA) (US) Duke University United States (USA) (US) University of Cambridge United Kingdom (GB) University of Hawaii (U.H.) United States (USA) (US) University College London (UCL) United Kingdom (GB) University of California Los Angeles (UCLA) United States (USA) (US) QIMR Berghofer Medical Research Institute (früher: the Queensland Institute of Medical Research) Australia (AU) Danish Cancer Society Denmark (DK)

How to cite

APA:

Lurie, G., Wilkens, L.R., Thompson, P.J., Shvetsov, Y.B., Matsuno, R.K., Carney, M.E.,... Goodman, M.T. (2011). Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk: Pooled analysis within the ovarian cancer association consortium. PLoS ONE, 6(6). https://doi.org/10.1371/journal.pone.0020703

MLA:

Lurie, Galina, et al. "Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk: Pooled analysis within the ovarian cancer association consortium." PLoS ONE 6.6 (2011).

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