The UGT1A6_19_GG genotype is a breast cancer risk factor

Justenhoven C, Obazee O, Winter S, Rabstein S, Lotz A, Harth V, Pesch B, Brüning T, Baisch C, Hartikainen JM, Mannermaa A, Kosma VM, Kataja V, Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M, Fasching P, Beckmann M, Ekici AB, Hein A, Hall P, Li J, Chang-Claude J, Flesch-Janys D, Seibold P, Rudolph A, Hamann U, Ko YD, Brauch H (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Frontiers in Genetics Frontiers Research Foundation / Frontiers Media

Book Volume: 4

Article Number: Article 104

Journal Issue: JUN

DOI: 10.3389/fgene.2013.00104

Abstract

Validation of an association between the UGT1A6_19_T>G (rs6759892) polymorphism and overall breast cancer risk. A pilot study included two population-based case-control studies from Germany (MARIE-GENICA). An independent validation study comprised four independent breast cancer case-control studies from Finland (KBCP, OBCS), Germany (BBCC), and Sweden (SASBAC). The pooled analysis included 7418 cases and 8720 controls from all six studies. Participants were of European descent. Genotyping was done by MALDI-TOF MS and statistical analysis was performed by logistic regression adjusted for age and study. The increased overall breast cancer risk for women with the UGT1A6_19_GG genotype which was observed in the pilot study was confirmed in the set of four independent study collections (OR 1.13, 95% CI 1.05-1.22; p = 0.001). The pooled study showed a similar effect (OR 1.09, 95% CI 1.04-1.14; p = 0.001). The risk effect on the basis of allele frequencies was highly significant, the pooled analysis showed an OR of 1.11 (95% CI 1.06-1.16; p = 5.8 × 10-6). We confirmed the association of UGT1A6_19_GG with increased overall breast cancer risk and conclude that our result from a well powered multi-stage study adds a novel candidate to the panel of validated breast cancer susceptibility loci. © 2013 Justenhoven, Obazee, Winter, Rabstein, Lotz, Harth, Pesch, Brüning, Baisch, Hartikainen, Mannermaa, Kosma, Kataja, Winqvist, Pylkäs, Jukkola-Vuorinen, Grip, Fasching, Beckmann, Ekici, Hein, Hall, Li, Chang-Claude, Flesch-Janys, Seibold, Rudolph, Hamann, Ko and Brauch.

Authors with CRIS profile

Peter Fasching Professur für Translationale Frauenheilkunde und Geburtshilfe Matthias Beckmann Lehrstuhl für Geburtshilfe und Frauenheilkunde Alexander Hein Department of Obstetrics and Gynaecology

Involved external institutions

Institut für Prävention und Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung (IPA) DE Germany (DE) Eberhard Karls Universität Tübingen DE Germany (DE) University of Eastern Finland FI Finland (FI) Oulu University Hospital FI Finland (FI) Karolinska Institute SE Sweden (SE) Deutsches Krebsforschungszentrum (DKFZ) DE Germany (DE) Johanniter GmbH DE Germany (DE) Genome Institute of Singapore SG Singapore (SG) Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE) University of California Los Angeles (UCLA) US United States (USA) (US) Kuopio University Hospital / Pohjois-Savon sairaanhoitopiiri FI Finland (FI)

How to cite

APA:

Justenhoven, C., Obazee, O., Winter, S., Rabstein, S., Lotz, A., Harth, V.,... Brauch, H. (2013). The UGT1A6_19_GG genotype is a breast cancer risk factor. Frontiers in Genetics, 4(JUN). https://doi.org/10.3389/fgene.2013.00104

MLA:

Justenhoven, Christina, et al. "The UGT1A6_19_GG genotype is a breast cancer risk factor." Frontiers in Genetics 4.JUN (2013).

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