The Genitourinary Pathology Society Update on Classification and Grading of Flat and Papillary Urothelial Neoplasia with New Reporting Recommendations and Approach to Lesions with Mixed and Early Patterns of Neoplasia

Amin MB, Comperat E, Epstein J, True LD, Hansel D, Paner GP, Al-Ahmadie H, Baydar D, Bivalacqua T, Brimo F, Cheng L, Cheville J, Dalbagni G, Falzarano S, Gordetsky J, Guo CC, Gupta S, Hes O, Iyer G, Kaushal S, Kunju L, Magi-Galluzzi C, Matoso A, Netto G, Osunkoya AO, Pan CC, Pivovarcikova K, Raspollini MR, Reis H, Rosenberg J, Roupret M, Shah RB, Shariat S, Trpkov K, Weyerer V, Zhou M, Mckenney J, Reuter VE (2021)

Publication Type: Journal article, Review article

Publication year: 2021

Journal

Book Volume: 28

Pages Range: 179-195

Journal Issue: 4

DOI: 10.1097/PAP.0000000000000308

Abstract

The Genitourinary Pathology Society (GUPS) undertook a critical review of the recent advances in bladder neoplasia with a focus on issues relevant to the practicing surgical pathologist for the understanding and effective reporting of bladder cancer, emphasizing particularly on the newly accumulated evidence post-2016 World Health Organization (WHO) classification. The work is presented in 2 manuscripts. Here, in the first, we revisit the nomenclature and classification system used for grading flat and papillary urothelial lesions centering on clinical relevance, and on dilemmas related to application in routine reporting. As patients of noninvasive bladder cancer frequently undergo cystoscopy and biopsy in their typically prolonged clinical course and for surveillance of disease, we discuss morphologies presented in these scenarios which may not have readily applicable diagnostic terms in the WHO classification. The topic of inverted patterns in urothelial neoplasia, particularly when prominent or exclusive, and beyond inverted papilloma has not been addressed formally in the WHO classification. Herein we provide a through review and suggest guidelines for when and how to report such lesions. In promulgating these GUPS recommendations, we aim to provide clarity on the clinical application of these not so uncommon diagnostically challenging situations encountered in routine practice, while also importantly advocating consistent terminology which would inform future work.

Authors with CRIS profile

Involved external institutions

Johns Hopkins Hospital United States (USA) (US) University of Alabama at Birmingham (UAB) United States (USA) (US) Emory University United States (USA) (US) Medizinische Universität Wien Austria (AT) Univerzita Karlova v Praze / Charles University in Prague Czech Republic (CZ) University of Paris 4 - Paris-Sorbonne / Université paris IV Paris-Sorbonne France (FR) Careggi University Hospital / Azienda Ospedaliero Universitaria Careggi Italy (IT) Taipei Veterans General Hospital / 台北榮民總醫院 Taiwan (TW) Universität Duisburg-Essen (UDE) Germany (DE) University of Calgary Canada (CA) Memorial Sloan Kettering Cancer Center United States (USA) (US) University of Texas Southwestern Medical Center (UT Southwestern) United States (USA) (US) Koç-Universität (KU) Turkey (TR) The University of Tennessee Health Science Center United States (USA) (US) Cleveland Clinic United States (USA) (US) Mayo Clinic United States (USA) (US) Vanderbilt University Medical Center United States (USA) (US) Vienna General Hospital / Allgemeines Krankenhaus der Stadt Wien (AKH) Austria (AT) University of Chicago United States (USA) (US) University of Florida United States (USA) (US) University of Washington United States (USA) (US) Tufts University United States (USA) (US) Indiana University – Purdue University Indianapolis United States (USA) (US) Oregon Health and Science University (OSHU) United States (USA) (US) University of Texas MD Anderson Cancer Center United States (USA) (US) All India Institute of Medical Sciences India (IN) University of Michigan United States (USA) (US)

How to cite

APA:

Amin, M.B., Comperat, E., Epstein, J., True, L.D., Hansel, D., Paner, G.P.,... Reuter, V.E. (2021). The Genitourinary Pathology Society Update on Classification and Grading of Flat and Papillary Urothelial Neoplasia with New Reporting Recommendations and Approach to Lesions with Mixed and Early Patterns of Neoplasia. Advances in Anatomic Pathology, 28(4), 179-195. https://doi.org/10.1097/PAP.0000000000000308

MLA:

Amin, Mahul B., et al. "The Genitourinary Pathology Society Update on Classification and Grading of Flat and Papillary Urothelial Neoplasia with New Reporting Recommendations and Approach to Lesions with Mixed and Early Patterns of Neoplasia." Advances in Anatomic Pathology 28.4 (2021): 179-195.

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