The Genitourinary Pathology Society Update on Classification of Variant Histologies, T1 Substaging, Molecular Taxonomy, and Immunotherapy and PD-L1 Testing Implications of Urothelial Cancers

Comperat E, Amin MB, Epstein J, Hansel DE, Pane G, Al-Ahmadie H, True L, Bayder D, Bivalacqua T, Brimo F, Cheng L, Cheville J, Dalbagni G, Falzarano S, Gordetsky J, Guo C, Gupta S, Hes O, Iyer G, Kaushal S, Kunju L, Magi-Galluzzi C, Matoso A, Mckenney J, Netto GJ, Osunkoya AO, Pan CC, Pivovarcikova K, Raspollini MR, Reis H, Rosenberg J, Roupret M, Shah RB, Shariat SF, Trpkov K, Weyerer V, Zhou M, Reuter V (2021)

Publication Type: Journal article, Review article

Publication year: 2021

Journal

Book Volume: 28

Pages Range: 196-208

Journal Issue: 4

DOI: 10.1097/PAP.0000000000000309

Abstract

The Genitourinary Pathology Society (GUPS) undertook a critical review of the recent advances in bladder cancer focusing on important topics of high interest for the practicing surgical pathologist and urologist. This review represents the second of 2 manuscripts ensuing from this effort. Herein, we address the effective reporting of bladder cancer, focusing particularly on newly published data since the last 2016 World Health Organization (WHO) classification. In addition, this review focuses on the importance of reporting bladder cancer with divergent differentiation and variant (subtypes of urothelial carcinoma) histologies and the potential impact on patient care. We provide new recommendations for reporting pT1 staging in diagnostic pathology. Furthermore, we explore molecular evolution and classification, emphasizing aspects that impact the understanding of important concepts relevant to reporting and management of patients.

Authors with CRIS profile

Involved external institutions

Cleveland Clinic United States (USA) (US) All India Institute of Medical Sciences India (IN) University of Chicago United States (USA) (US) Memorial Sloan Kettering Cancer Center United States (USA) (US) Taipei Veterans General Hospital / 台北榮民總醫院 Taiwan (TW) Careggi University Hospital / Azienda Ospedaliero Universitaria Careggi Italy (IT) Medizinische Universität Wien Austria (AT) University of Alabama at Birmingham (UAB) United States (USA) (US) University of Calgary Canada (CA) Univerzita Karlova v Praze / Charles University in Prague Czech Republic (CZ) University of Michigan United States (USA) (US) Johns Hopkins Hospital United States (USA) (US) Vanderbilt University Medical Center United States (USA) (US) University of Paris 4 - Paris-Sorbonne / Université paris IV Paris-Sorbonne France (FR) Koç-Universität (KU) Turkey (TR) Tufts University United States (USA) (US) Mayo Clinic United States (USA) (US) University of South Florida (USF) United States (USA) (US) University of Washington United States (USA) (US) Indiana University – Purdue University Indianapolis United States (USA) (US) The University of Tennessee Health Science Center United States (USA) (US) Emory University United States (USA) (US) University of Texas Southwestern Medical Center (UT Southwestern) United States (USA) (US) University of Texas MD Anderson Cancer Center United States (USA) (US) Oregon Health and Science University (OSHU) United States (USA) (US) Universität Duisburg-Essen (UDE) Germany (DE)

How to cite

APA:

Comperat, E., Amin, M.B., Epstein, J., Hansel, D.E., Pane, G., Al-Ahmadie, H.,... Reuter, V. (2021). The Genitourinary Pathology Society Update on Classification of Variant Histologies, T1 Substaging, Molecular Taxonomy, and Immunotherapy and PD-L1 Testing Implications of Urothelial Cancers. Advances in Anatomic Pathology, 28(4), 196-208. https://doi.org/10.1097/PAP.0000000000000309

MLA:

Comperat, Eva, et al. "The Genitourinary Pathology Society Update on Classification of Variant Histologies, T1 Substaging, Molecular Taxonomy, and Immunotherapy and PD-L1 Testing Implications of Urothelial Cancers." Advances in Anatomic Pathology 28.4 (2021): 196-208.

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