Plant kinesin-12: Localization heterogeneity and functional implications

Livanos P, Müller S (2019)

Publication Type: Journal article, Review article

Publication year: 2019


Book Volume: 20

Article Number: 4213

Journal Issue: 17

DOI: 10.3390/ijms20174213


Kinesin-12 family members are characterized by an N-terminal motor domain and the extensive presence of coiled-coil domains. Animal orthologs display microtubule plus-end directed motility, bundling of parallel and antiparallel microtubules, plus-end stabilization, and they play a crucial role in spindle assembly. In plants, kinesin-12 members mediate a number of developmental processes including male gametophyte, embryo, seedling, and seed development. At the cellular level, they participate in critical events during cell division. Several kinesin-12 members localize to the phragmoplast midzone, interact with isoforms of the conserved microtubule cross-linker MICROTUBULE-ASSOCIATED PROTEIN 65 (MAP65) family, and are required for phragmoplast stability and expansion, as well as for proper cell plate development. Throughout cell division, a subset of kinesin-12 reside, in addition or exclusively, at the cortical division zone and mediate the accurate guidance of the phragmoplast. This review aims to summarize the current knowledge on kinesin-12 in plants and shed some light onto the heterogeneous localization and domain architecture, which potentially conceals functional diversification.

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Livanos, P., & Müller, S. (2019). Plant kinesin-12: Localization heterogeneity and functional implications. International Journal of Molecular Sciences, 20(17).


Livanos, Pantelis, and Sabine Müller. "Plant kinesin-12: Localization heterogeneity and functional implications." International Journal of Molecular Sciences 20.17 (2019).

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