Extracellular vesicles as antigen carriers for novel vaccination avenues

Mehanny M, Lehr CM, Fuhrmann G (2021)

Publication Type: Journal article, Review article

Publication year: 2021


Book Volume: 173

Pages Range: 164-180

DOI: 10.1016/j.addr.2021.03.016


Antigen delivery has always been a challenge in scientific practice of vaccine formulation. Yet, mammalian extracellular vesicles (EVs) or bacterial membrane vesicles (MVs) provide an innovative avenue for safe and effective delivery of antigenic material. They include intrinsically loaded antigens from EV-secreting cells or extrinsically loaded antigens onto pre-formed vesicles. Interestingly, many studies shed light on potential novel anti-cancer vaccination immunotherapy for therapeutic applications from mammalian cell host-derived EVs, as well as conventional vaccination for prophylactic applications using bacterial cell-derived MVs against infectious diseases. Here, we discuss the rationale, status quo and potential for both vaccine applications using EVs.

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Mehanny, M., Lehr, C.M., & Fuhrmann, G. (2021). Extracellular vesicles as antigen carriers for novel vaccination avenues. Advanced Drug Delivery Reviews, 173, 164-180. https://doi.org/10.1016/j.addr.2021.03.016


Mehanny, Mina, Claus Michael Lehr, and Gregor Fuhrmann. "Extracellular vesicles as antigen carriers for novel vaccination avenues." Advanced Drug Delivery Reviews 173 (2021): 164-180.

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