Esterification vs. 1,3-Dipolar Cycloaddition Synthetic Approaches for Preparation of the Fluorescently Labelled Iron(II) Clathrochelates
Selin RA, Chernii VY, Kryvorotenko D, Mokhir A, Voloshin YZ (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 14
Pages Range: 94-100
Journal Issue: 1
DOI: 10.6060/mhc201230v
Abstract
Two most common synthetic approaches (i.e. the esterification and 1,3-dipolar cycloaddition reactions) to a functionalization of the reactive three-dimensional molecular platforms, allowing to obtain the fluorescently labelled iron(II) clathrochelates and, therefore, to study their localization and accumulation in cancer cells, were compared. Because an esterification approach gave the target complexes in a very low yield, if any, such a functionalization of a known propargylamine iron(II) clathrochelate complex with terminal C C bond as a reactive macrobicyclic precursor by the copper-promoted 1,3-dipolar cycloaddition "click" reaction was also tested. This one-pot synthetic procedure allowed to obtain the cumarin-terminated iron(II) cage complex in a high yield; it was characterized using elemental analysis, ESI-TOF mass, and H-1 and C-13{H-1} NMR spectra.
Authors with CRIS profile
Involved external institutions
Vernadsky Institute of general and inorganic chemistry / Інститут загальної та неорганічної хімії імені В. I. Вернадського НАН України
Ukraine (UA)
National Academy of Sciences of Ukraine (NAN) / Національна академія наук України
Ukraine (UA)
Russian Academy of Sciences / Росси́йская акаде́мия нау́к (RAS)
Russian Federation (RU)
Ukraine (UA)
National Academy of Sciences of Ukraine (NAN) / Національна академія наук України
Ukraine (UA)
Russian Academy of Sciences / Росси́йская акаде́мия нау́к (RAS)
Russian Federation (RU)
How to cite
APA:
Selin, R.A., Chernii, V.Y., Kryvorotenko, D., Mokhir, A., & Voloshin, Y.Z. (2021). Esterification vs. 1,3-Dipolar Cycloaddition Synthetic Approaches for Preparation of the Fluorescently Labelled Iron(II) Clathrochelates. Journal Macroheterocycles, 14(1), 94-100. https://doi.org/10.6060/mhc201230v
MLA:
Selin, Roman A., et al. "Esterification vs. 1,3-Dipolar Cycloaddition Synthetic Approaches for Preparation of the Fluorescently Labelled Iron(II) Clathrochelates." Journal Macroheterocycles 14.1 (2021): 94-100.
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