Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla

Hartmann B, Müller M, Seyler L, Bäuerle T, Wilferth T, Avdievitch N, Ruhm L, Henning A, Lesiv A, Ivashkin P, Uder M, Nagel AM (2021)

Publication Type: Journal article

Publication year: 2021


Book Volume: 16

Article Number: e0252935

Journal Issue: 6 June

DOI: 10.1371/journal.pone.0252935


Deuterium Magnetic Resonance Spectroscopy (DMRS) is a non-invasive technique that allows the detection of deuterated compounds in vivo. DMRS has a large potential to analyze uptake, perfusion, washout or metabolism, since deuterium is a stable isotope and therefore does not decay during biologic processing of a deuterium labelled substance. Moreover, DMRS allows the distinction between different deuterated substances. In this work, we performed DMRS of deuterated 3-O-Methylglucose (OMG). OMG is a non-metabolizable glucose analog which is transported similar to D-glucose. DMRS of OMG was performed in phantom and in vivo measurements using a preclinical 7 Tesla MRI system. The chemical shift (3.51 ± 0.1 ppm) and relaxation times were determined. OMG was injected intravenously and spectra were acquired over a period of one hour to monitor the time evolution of the deuterium signal in tumor-bearing rats. The increase and washout of OMG could be observed. Three different exponential functions were compared in terms of how well they describe the OMG washout. A mono-exponential model with offset seems to describe the observed time course best with a time constant of 1910 ± 770 s and an offset of 2.5 ± 1.2 mmol/l (mean ± std, N = 3). Chemical shift imaging could be performed with a voxel size of 7.1 mm × 7.1 mm × 7.9 mm. The feasibility of DMRS with deuterium labelled OMG could be demonstrated. These data might serve as basis for future studies that aim to characterize glucose transport using DMRS.

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Hartmann, B., Müller, M., Seyler, L., Bäuerle, T., Wilferth, T., Avdievitch, N.,... Nagel, A.M. (2021). Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla. PLoS ONE, 16(6 June). https://doi.org/10.1371/journal.pone.0252935


Hartmann, Benedikt, et al. "Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla." PLoS ONE 16.6 June (2021).

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