Imaging of Functional Brain Circuits during Acquisition and Memory Retrieval in an Aversive Feedback Learning Task: Single Photon Emission Computed Tomography of Regional Cerebral Blood Flow in Freely Behaving Rats

Braun K, Mannewitz A, Bock J, Kreitz S, Heß A, Scheich H, Goldschmidt J (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Brain Sciences MDPI

Book Volume: 11

Journal Issue: 5

DOI: 10.3390/brainsci11050659

Abstract

Active avoidance learning is a complex form of aversive feedback learning that in humans and other animals is essential for actively coping with unpleasant, aversive, or dangerous situations. Since the functional circuits involved in two-way avoidance (TWA) learning have not yet been entirely identified, the aim of this study was to obtain an overall picture of the brain circuits that are involved in active avoidance learning. In order to obtain a longitudinal assessment of activation patterns in the brain of freely behaving rats during different stages of learning, we applied single-photon emission computed tomography (SPECT). We were able to identify distinct prefrontal cortical, sensory, and limbic circuits that were specifically recruited during the acquisition and retrieval phases of the two-way avoidance learning task.

Authors with CRIS profile

Silke Kreitz Lehrstuhl für Pharmakologie und Toxikologie Andreas Heß Medizinische Fakultät

Involved external institutions

Otto-von-Guericke-Universität Magdeburg DE Germany (DE) Zentrum für neurowissenschaftliche Forschung / Center for Behavioral Brain Sciences (CBBS) DE Germany (DE)

How to cite

APA:

Braun, K., Mannewitz, A., Bock, J., Kreitz, S., Heß, A., Scheich, H., & Goldschmidt, J. (2021). Imaging of Functional Brain Circuits during Acquisition and Memory Retrieval in an Aversive Feedback Learning Task: Single Photon Emission Computed Tomography of Regional Cerebral Blood Flow in Freely Behaving Rats. Brain Sciences, 11(5). https://dx.doi.org/10.3390/brainsci11050659

MLA:

Braun, Katharina, et al. "Imaging of Functional Brain Circuits during Acquisition and Memory Retrieval in an Aversive Feedback Learning Task: Single Photon Emission Computed Tomography of Regional Cerebral Blood Flow in Freely Behaving Rats." Brain Sciences 11.5 (2021).

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