Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

Sadegh S, Matschinske J, Blumenthal DB, Galindez G, Kacprowski T, List M, Nasirigerdeh R, Oubounyt M, Pichlmair A, Rose TD, Salgado-Albarran M, Spaeth J, Stukalov A, Wenke NK, Yuan K, Pauling JK, Baumbach J (2020)

Publication Type: Journal article

Publication year: 2020


Book Volume: 11

Article Number: 3518

Journal Issue: 1

DOI: 10.1038/s41467-020-17189-2


Coronavirus Disease-2019 (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. Various studies exist about the molecular mechanisms of viral infection. However, such information is spread across many publications and it is very time-consuming to integrate, and exploit. We develop CoVex, an interactive online platform for SARS-CoV-2 host interactome exploration and drug (target) identification. CoVex integrates virus-human protein interactions, human protein-protein interactions, and drug-target interactions. It allows visual exploration of the virus-host interactome and implements systems medicine algorithms for network-based prediction of drug candidates. Thus, CoVex is a resource to understand molecular mechanisms of pathogenicity and to prioritize candidate therapeutics. We investigate recent hypotheses on a systems biology level to explore mechanistic virus life cycle drivers, and to extract drug repurposing candidates. CoVex renders COVID-19 drug research systems-medicine-ready by giving the scientific community direct access to network medicine algorithms. It is available at https://exbio.wzw.tum.de/covex/.

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Sadegh, S., Matschinske, J., Blumenthal, D.B., Galindez, G., Kacprowski, T., List, M.,... Baumbach, J. (2020). Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing. Nature Communications, 11(1). https://doi.org/10.1038/s41467-020-17189-2


Sadegh, Sepideh, et al. "Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing." Nature Communications 11.1 (2020).

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