Genetic variants associated with methotrexate-induced mucositis in cancer treatment: A systematic review and meta-analysis
Maagdenberg H, Oosterom N, Zanen J, Gemmati D, Windsor RE, Heil SG, Esperón P, Jabeen S, Ruiz-Argüelles GJ, Zolk O, Hörning S, Sleurs C, Lopéz-Lopéz E, Moreno-Galván M, van den Heuvel-Eibrink MM, Maitland-van der Zee AH, Carleton BC (2021)
Publication Type: Journal article, Review article
Publication year: 2021
Journal
Book Volume: 161
Article Number: 103312
DOI: 10.1016/j.critrevonc.2021.103312
Abstract
Methotrexate (MTX), an important chemotherapeutic agent, is often accompanied with mucositis. The occurrence and severity are unpredictable and show large interindividual variability. In this study, we review and meta-analyze previously studied genetic variants in relation to MTX-induced mucositis. We conducted a systematic search in Medline and Embase. We included genetic association studies of MTX-induced mucositis in cancer patients. A meta-analysis was conducted for single nucleotide polymorphisms (SNPs) for which at least two studies found a statistically significant association. A total of 34 SNPs were associated with mucositis in at least one study of the 57 included studies. Two of the seven SNPs included in our meta-analysis were statistically significantly associated with mucositis: MTHFR c.677C > T (recessive, grade ≥3 vs grade 0–2, OR 2.53, 95 %CI [1.48–4.32], False Discovery Rate[FDR]-corrected p-value 0.011) and MTRR c.66A > G (overdominant, grade ≥1 vs grade 0, OR 2.08, 95 %CI [1.16–3.73], FDR-corrected p-value 0.042).
Authors with CRIS profile
Involved external institutions
University of the Republic / Universidad de la República (UdelaR)
Uruguay (UY)
Università degli Studi di Ferrara
Italy (IT)
University College London Hospitals (UCLH)
United Kingdom (GB)
Erasmus University Medical Center (MC)
Netherlands (NL)
Akershus University Hospital / Akershus universitetssykehus (Ahus)
Norway (NO)
Clinica Ruiz
Mexico (MX)
Universitätsklinikum Ulm
Germany (DE)
Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven
Belgium (BE)
University of Basque Country / Universidad del Pais Vasco (UPV) / Euskal Herriko Unibersitatea (EHU)
Spain (ES)
BC Children's Hospital Research Institute
Canada (CA)
Princess Máxima Center
Netherlands (NL)
University of British Columbia
Canada (CA)
Hospital Infantil de México Federico Gómez
Mexico (MX)
Amsterdam University Medical Centers (Amsterdam UMC) / Amsterdam Universitair Medische Centra
Netherlands (NL)
Uruguay (UY)
Università degli Studi di Ferrara
Italy (IT)
University College London Hospitals (UCLH)
United Kingdom (GB)
Erasmus University Medical Center (MC)
Netherlands (NL)
Akershus University Hospital / Akershus universitetssykehus (Ahus)
Norway (NO)
Clinica Ruiz
Mexico (MX)
Universitätsklinikum Ulm
Germany (DE)
Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven
Belgium (BE)
University of Basque Country / Universidad del Pais Vasco (UPV) / Euskal Herriko Unibersitatea (EHU)
Spain (ES)
BC Children's Hospital Research Institute
Canada (CA)
Princess Máxima Center
Netherlands (NL)
University of British Columbia
Canada (CA)
Hospital Infantil de México Federico Gómez
Mexico (MX)
Amsterdam University Medical Centers (Amsterdam UMC) / Amsterdam Universitair Medische Centra
Netherlands (NL)
How to cite
APA:
Maagdenberg, H., Oosterom, N., Zanen, J., Gemmati, D., Windsor, R.E., Heil, S.G.,... Carleton, B.C. (2021). Genetic variants associated with methotrexate-induced mucositis in cancer treatment: A systematic review and meta-analysis. Critical Reviews in Oncology Hematology, 161. https://doi.org/10.1016/j.critrevonc.2021.103312
MLA:
Maagdenberg, Hedy, et al. "Genetic variants associated with methotrexate-induced mucositis in cancer treatment: A systematic review and meta-analysis." Critical Reviews in Oncology Hematology 161 (2021).
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