Früh- und Spättoxizitäten sowie sozialmedizinisch-relevante Folgestörungen bei Brustkrebs-Patientinnen als Basis der Abschätzung des Reha-Bedarfes
Hass HG, Seywald M, Stepien J, Muco B, Tanriverdi M, Beckmann M, Kunzmann V, Wöckel A (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 60
Pages Range: 77-85
Journal Issue: 2
DOI: 10.1055/a-1361-3666
Abstract
Introduction Reasonable to the improved prognosis of breast cancer (BC) long-term toxicities and side effects of oncological therapy gain more importance for work ability and social life of BC patients. Aim of this study was the analysis of occurence and differences of treatment-related side effects in relation to type of rehabilitation (so-called AHB vs. later rehabilitation) after therapy for BC. Methods Clinical and patient related data as early and late toxicities after oncological treatment of 8.000 patients with BC (55.7±10.4y) were analyzed and compared with current literature. Results In 23.9% a mastectomy was performed, in 87.3% radiotherapy. In most cases an additional systemic treatment (57,6% CTX, 15,1% anti-Her2, 71% antihormonal treatment) was carried out. In 8.1% women suffered from recurrent or metastatic BC. As most common side effects of multimodal treatment weakness/fatigue (73,6%), insomnia (51,9%), CIPN (33%), lymph edema (13,9%) and drug-induced arthralgia (24,8%) were detected. In addition, 60.4% of women reported high levels of psychological distress. Shortly after therapy typical side effects were drug-induced toxicities (Leucopenia, p<0.0001; anemia, p<0.001; weakness/fatigue p<0.001; CIPN, p<0.0001), whereas in a later course chronic lymphedema (p<0.0001), chronic or recurrent disease (p<0.0001), status after mastectomy (p<0.0001) and psychological distress (p<0.0001) were significantly more often seen. Moreover, in this collective patients were significantly younger (53,7±9,8 vs. 56,3±10,7y). Conclusions In BC patients, significantly different impairments and toxicities were documented between patients with early rehabilitation and patients with later onset of rehabilitation. These data may help to establish more individual and focused rehabilitation concepts in specialized centers.
Authors with CRIS profile
Involved external institutions
Paracelsus-Kliniken Deutschland
Germany (DE)
Julius-Maximilians-Universität Würzburg
Germany (DE)
Universitätsklinikum Würzburg
Germany (DE)
Germany (DE)
Julius-Maximilians-Universität Würzburg
Germany (DE)
Universitätsklinikum Würzburg
Germany (DE)
How to cite
APA:
Hass, H.G., Seywald, M., Stepien, J., Muco, B., Tanriverdi, M., Beckmann, M.,... Wöckel, A. (2021). Früh- und Spättoxizitäten sowie sozialmedizinisch-relevante Folgestörungen bei Brustkrebs-Patientinnen als Basis der Abschätzung des Reha-Bedarfes. Rehabilitation, 60(2), 77-85. https://doi.org/10.1055/a-1361-3666
MLA:
Hass, Holger G., et al. "Früh- und Spättoxizitäten sowie sozialmedizinisch-relevante Folgestörungen bei Brustkrebs-Patientinnen als Basis der Abschätzung des Reha-Bedarfes." Rehabilitation 60.2 (2021): 77-85.
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