Quantifying progression in primary progressive aphasia with structural neuroimaging

Lombardi J, Mayer B, Semler E, Anderl-Straub S, Uttner I, Kassubek J, Diehl-Schmid J, Danek A, Levin J, Fassbender K, Fliessbach K, Schneider A, Huppertz HJ, Jahn H, Volk A, Kornhuber J, Landwehrmeyer B, Lauer M, Prudlo J, Wiltfang J, Schroeter ML, Ludolph A, Otto M (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Alzheimers & Dementia Elsevier Masson

DOI: 10.1002/alz.12323

Abstract

Introduction: The term primary progressive aphasia (PPA) sums up the non-fluent (nfv), the semantic (sv), and the logopenic (lv) variant. Up to now, there is only limited data available concerning magnetic resonance imaging volumetry to monitor disease progression. Methods: Structural brain imaging and an extensive assessment were applied at baseline and up to 4-year(s) follow-up in 269 participants. With automated atlas-based volumetry 56 brain regions were assessed. Atrophy progression served to calculate sample sizes for therapeutic trials. Results: At baseline highest atrophy appeared in parts of the left frontal lobe for nfvPPA (–17%) and of the left temporal lobe for svPPA (–34%) and lvPPA (–24%). Severest progression within 1-year follow-up occurred in the basal ganglia in nfvPPA (–7%), in the hippocampus/amygdala in svPPA (–9%), and in (medial) temporal regions in lvPPA (–6%). Conclusion: PPA presents as a left-dominant, mostly gray matter sensitive disease with considerable atrophy at baseline that proceeds variant-specific.

Authors with CRIS profile

Johannes Kornhuber Lehrstuhl für Psychiatrie und Psychotherapie

Involved external institutions

Universitätsklinikum Leipzig DE Germany (DE) Universitätsklinikum Ulm DE Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE) Technische Universität München (TUM) DE Germany (DE) Schweizerisches Epilepsie-Zentrum CH Switzerland (CH) Universitätsmedizin Rostock DE Germany (DE) Universitätsklinikum des Saarlandes (UKS) DE Germany (DE) Universitätsklinikum Bonn DE Germany (DE) Ludwig-Maximilians-Universität (LMU) DE Germany (DE) Georg-August-Universität Göttingen DE Germany (DE) Universität Ulm DE Germany (DE) Universitätsklinikum Würzburg DE Germany (DE)

How to cite

APA:

Lombardi, J., Mayer, B., Semler, E., Anderl-Straub, S., Uttner, I., Kassubek, J.,... Otto, M. (2021). Quantifying progression in primary progressive aphasia with structural neuroimaging. Alzheimers & Dementia. https://doi.org/10.1002/alz.12323

MLA:

Lombardi, Jolina, et al. "Quantifying progression in primary progressive aphasia with structural neuroimaging." Alzheimers & Dementia (2021).

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